Literature Review - New Abstracts Sept-Nov 2001

The following is a summary of some of the new journal articles I thought merited a closer look. These were entered into the PubMed database Sept-Nov 2001. I have marked with >>> those abstracts I thought were particularly important.

CONTENTS
1. NEW DRUGS
2. CHEMOTHERAPY
3. PROGNOSIS
4. COX-2 and COX-2 Inhibitors
5. JAPANESE RESEARCH
6. ALTERNATIVE MEDICINE
7. DIET
8. HNPCC/Microsatellite Instability
9. COLONOSCOPY
10. MISCELLANEOUS


  1. NEW DRUGS

    Ding Z, Parchment RE, LoRusso PM, Zhou JY, Li J, Lawrence TS, Sun Y, Wu GS.
    The Investigational New Drug XK469 Induces G(2)-M Cell Cycle Arrest by p53-dependent and -independent Pathways.
    Clin Cancer Res. 2001 Nov;7(11):3336-3342. PMID: 11705845 [PubMed - as supplied by publisher]

    Ozawa Y, Sugi NH, Nagasu T, Owa T, Watanabe T, Koyanagi N, Yoshino H, Kitoh K, Yoshimatsu K.
    E7070, a novel sulphonamide agent with potent antitumour activity in vitro and in vivo.
    Eur J Cancer. 2001;37(17):2275-82. PMID: 11677118 [PubMed - in process]

    Green DW, Roh H, Pippin JA, Drebin JA.
    beta-Catenin Antisense Treatment Decreases beta-Catenin Expression and Tumor Growth Rate in Colon Carcinoma Xenografts.
    J Surg Res. 2001 Nov;101(1):16-20. PMID: 11676549 [PubMed - in process]

    Kawaguchi M, Hosotani R, Ohishi S, Fujii N, Singh Tulachan S, Koizumi M, Toyoda E, Masui T, Nakajima S, Tsuji S, Ida J, Fujimoto K, Wada M, Doi R, Imamura M.
    A novel synthetic arg-gly-asp-containing peptide cyclo(-rgdf&dbond;v-) is the potent inhibitor of angiogenesis.
    Biochem Biophys Res Commun. 2001 Nov 2;288(3):711-7. PMID: 11676501 [PubMed - in process]

    Easmon J, Puerstinger G, Roth T, Fiebig HH, Jenny M, Jaeger W, Heinisch G, Hofmann J.
    2-benzoxazolyl and 2-benzimidazolyl hydrazones derived from 2-acetylpyridine: a novel class of antitumor agents.
    Int J Cancer. 2001 Oct 1;94(1):89-96. PMID: 11668483 [PubMed - indexed for MEDLINE]

    Cosentini E, Haberl I, Pertschy P, Teleky B, Mallinger R, Baumgartner G, Wenzl E, Hamilton G.
    The differentiation inducers phenylacetate and phenylbutyrate modulate camptothecin sensitivity in colon carcinoma cells in vitro by intracellular acidification.
    Int J Oncol. 2001 Nov;19(5):1069-74. PMID: 11605011 [PubMed - in process]

    Inufusa H, Adachi T, Kiyokawa T, Nakatani Y, Wakano T, Nakamura M, Okuno K, Shiozaki H, Yamamoto S, Suzuki M, Ando O, Kurimoto M, Miyake M, Yasutomi M.
    Ley glycolipid-recognizing monoclonal antibody inhibits procoagulant activity and metastasis of human adenocarcinoma.
    Int J Oncol. 2001 Nov;19(5):941-6. PMID: 11604991 [PubMed - in process]

    Oh YS, Kim EJ, Schaffer BS, Kang YH, Binderup L, MacDonald RG, Park JH.
    Synthetic low-calcaemic vitamin D(3) analogues inhibit secretion of insulin-like growth factor II and stimulate production of insulin-like growth factor-binding protein-6 in conjunction with growth suppression of HT-29 colon cancer cells.
    Mol Cell Endocrinol. 2001 Oct 25;183(1-2):141-9. PMID: 11604234 [PubMed - in process]

    Nishizuka I, Ichikawa Y, Ishikawa T, Kamiyama M, Hasegawa S, Momiyama N, Miyazaki K, Shimada H.
    Matrilysin stimulates DNA synthesis of cultured vascular endothelial cells and induces angiogenesis in vivo.
    Cancer Lett. 2001 Nov 28;173(2):175-82. PMID: 11597792 [PubMed - in process]

    Kinuya S, Kawashima A, Yokoyama K, Kudo M, Kasahara Y, Watanabe N, Shuke N, Bunko H, Michigishi T, Tonami N.
    Anti-angiogenic therapy and radioimmunotherapy in colon cancer xenografts.
    Eur J Nucl Med. 2001 Sep;28(9):1306-12. PMID: 11585288 [PubMed - in process]

    Schwartzberg LS.
    Clinical experience with edrecolomab: a monoclonal antibody therapy for colorectal carcinoma.
    Crit Rev Oncol Hematol. 2001 Oct;40(1):17-24. PMID: 11578913 [PubMed - in process]

    Lanzafame RJ.
    Surgical evolution: clinical practice catching up to tumor biology in breast and colon cancer.
    J Clin Laser Med Surg. 2000 Aug;18(4):171-2. No abstract available. PMID: 11573508 [PubMed - indexed for MEDLINE]

    van Niekerk E, O'Sullivan JF, Joone GK, van Rensburg CE.
    Tetramethylpiperidine-substituted phenazines inhibit the proliferation of intrinsically multidrug resistant carcinoma cell lines.
    Invest New Drugs. 2001;19(3):211-7. PMID: 11561677 [PubMed - in process]

    Huang Y, He Q, Hillman MJ, Rong R, Sheikh MS.
    Sulindac sulfide-induced apoptosis involves death receptor 5 and the caspase 8-dependent pathway in human colon and prostate cancer cells.
    Cancer Res. 2001 Sep 15;61(18):6918-24. PMID: 11559570 [PubMed - indexed for MEDLINE]

    Tofani S, Barone D, Cintorino M, de Santi MM, Ferrara A, Orlassino R, Ossola P, Peroglio F, Rolfo K, Ronchetto F.
    Static and ELF magnetic fields induce tumor growth inhibition and apoptosis.
    Bioelectromagnetics. 2001 Sep;22(6):419-28. PMID: 11536283 [PubMed - indexed for MEDLINE]

    >>>>>van den Tol MP, Haverlag R, van Rossen ME, Bonthuis F, Marquet RL, Jeekel J.
    Glove powder promotes adhesion formation and facilitates tumour cell adhesion and growth.
    Br J Surg. 2001 Sep;88(9):1258-63. PMID: 11531877 [PubMed - indexed for MEDLINE]

    Darmoul D, Marie JC, Devaud H, Gratio V, Laburthe M.
    Initiation of human colon cancer cell proliferation by trypsin acting at protease-activated receptor-2.
    Br J Cancer. 2001 Sep 1;85(5):772-9. PMID: 11531266 [PubMed - indexed for MEDLINE]

  2. CHEMOTHERAPY

    >>>>>>Van Cutsem E, Twelves C, Cassidy J, Allman D, Bajetta E, Boyer M, Bugat R, Findlay M, Frings S, Jahn M, McKendrick J, Osterwalder B, Perez-Manga G, Rosso R, Rougier P, Schmiegel WH, Seitz JF, Thompson P, Vieitez JM, Weitzel C, Harper P.
    Oral Capecitabine Compared With Intravenous Fluorouracil Plus Leucovorin in Patients With Metastatic Colorectal Cancer: Results of a Large Phase III Study.
    J Clin Oncol. 2001 Nov 1;19(21):4097-106. PMID: 11689577 [PubMed - in process]

    Guichard S, Arnould S, Hennebelle I, Bugat R, Canal P.
    Combination of oxaliplatin and irinotecan on human colon cancer cell lines: activity in vitro and in vivo.
    Anticancer Drugs. 2001 Oct;12(9):741-51. PMID: 11593056 [PubMed - in process]

    Hwang PM, Bunz F, Yu J, Rago C, Chan TA, Murphy MP, Kelso GF, Smith RA, Kinzler KW, Vogelstein B
    Ferredoxin reductase affects p53-dependent, 5-fluorouracil-induced apoptosis in colorectal cancer cells.
    Nat Med. 2001 Oct;7(10):1111-7. PMID: 11590433 [PubMed - indexed for MEDLINE]

    Augenlicht LH, Wadler S, Arango D.
    Clinical response to fluorouracil and p53.
    N Engl J Med. 2001 Oct 4;345(14):1065-6. No abstract available. PMID: 11586966 [PubMed - indexed for MEDLINE]

    >>>>Yamamoto T, Inoue F, Mutoh T, Tatematsu H, Yamataka K, Sakurai T, Kawahara H.
    [A case of intra-peritoneal recurrence of colon carcinoma that responded remarkably to combined therapy of low-dose leucovorin and 5-fluorouracil].
    Gan To Kagaku Ryoho. 2001 Sep;28(9):1291-4. Japanese. PMID: 11579643 [PubMed - indexed for MEDLINE]

    Van Laethem JL.
    Adjuvant treatment for colorectal cancer.
    Acta Gastroenterol Belg. 2001 Jul-Sep;64(3):263-7. PMID: 11680045 [PubMed - in process]

  3. PROGNISIS

    Manne U, Gary BD, Oelschlager DK, Weiss HL, Frost AR, Grizzle WE.
    Altered subcellular localization of suppressin, a novel inhibitor of cell-cycle entry, is an independent prognostic factor in colorectal adenocarcinomas.
    Clin Cancer Res. 2001 Nov;7(11):3495-503. PMID: 11705868 [PubMed - in process]

    Burdy G, Panis Y, Alves A, Nemeth J, Lavergne-Slove A, Valleur P.
    Identifying patients with t3-t4 node-negative colon cancer at high risk of recurrence.
    Dis Colon Rectum. 2001 Nov;44(11):1682-8. PMID: 11711742 [PubMed - in process]

    Perrin J, Gouvernet J, Parriaux D, Noguchi T, Giovannini MH, Giovannini M, Delpero JR, Birnbaum D, Monges G
    MSH2 and MLH1 immunodetection and the prognosis of colon cancer.
    Int J Oncol. 2001 Nov;19(5):891-5. PMID: 11604984 [PubMed - in process]

    Oya M, Akiyama Y, Okuyama T, Ishikawa H.
    High preoperative plasma D-dimer level is associated with advanced tumor stage and short survival after curative resection in patients with colorectal cancer.
    Jpn J Clin Oncol. 2001 Aug;31(8):388-94. PMID: 11574632 [PubMed - indexed for MEDLINE]

    Lenander C, Habermann JK, Ost A, Nilsson B, Schimmelpenning H, Tryggvason K, Auer G.
    Laminin-5 gamma2 chain expression correlates with unfavorable prognosis in colon carcinomas.
    Anal Cell Pathol. 2001;22(4):201-9. PMID: 11564896 [PubMed - in process]

  4. COX-2 and COX-2 INHIBITORS

    Bing RJ, Miyataka M, Rich KA, Hanson N, Wang X, Slosser HD, Shi SR.
    Nitric oxide, prostanoids, cyclooxygenase, and angiogenesis in colon and breast cancer.
    Clin Cancer Res. 2001 Nov;7(11):3385-92. PMID: 11705852 [PubMed - in process]

    Calatayud S, Warner TD, Breese EJ, Mitchell JA.
    Relationship between endogenous colony stimulating factors and apoptosis in human colon cancer cells: role of cyclo-oxygenase inhibitors.
    Br J Pharmacol. 2001 Nov 6;134(6):1237-1244. PMID: 11704643 [PubMed - as supplied by publisher]

    Fosslien E.
    Review: molecular pathology of cyclooxygenase-2 in cancer-induced angiogenesis.
    Ann Clin Lab Sci. 2001 Oct;31(4):325-48. PMID: 11688844 [PubMed - in process]

    Williams CS, Sheng H, Brockman JA, Armandla R, Shao J, Washington MK, Elkahloun AG, DuBois RN.
    A Cyclooxygenase-2 Inhibitor (SC-58125) Blocks Growth of Established Human Colon Cancer Xenografts.
    Neoplasia. 2001 Sep-Oct;3(5):428-36. PMID: 11687954 [PubMed - in process]

    Grosch S, Tegeder I, Niederberger E, Brautigam L, Geisslinger G.
    COX-2 independent induction of cell cycle arrest and apoptosis in colon cancer cells by the selective COX-2 inhibitor celecoxib.
    FASEB J. 2001 Oct 15 [epub ahead of print] PMID: 11606477 [PubMed - as supplied by publisher]

    Pyo H, Choy H, Amorino GP, Kim Js, Cao Q, Hercules SK, DuBois RN.
    A selective cyclooxygenase-2 inhibitor, ns-398, enhances the effect of radiation in vitro and in vivo preferentially on the cells that express cyclooxygenase-2.
    Clin Cancer Res. 2001 Oct;7(10):2998-3005. PMID: 11595687 [PubMed - in process]

    Yang WL, Frucht H.
    Activation of the PPAR pathway induces apoptosis and COX-2 inhibition in HT-29 human colon cancer cells.
    Carcinogenesis. 2001 Sep;22(9):1379-83. PMID: 11532858 [PubMed - indexed for MEDLINE]

  5. JAPANESE RESEARCH

    Ishihara K, Tanemura H, Ohshita H, Kanno A, Kusakabe M, Hatou T, Tonomura S, Hosono Y, Sasaki Y.
    [A case of multiple liver metastases from sigmoid colon cancer effectively treated by hepatic intra-arterial administration of levoforinate and 5-fluorouracil].
    Gan To Kagaku Ryoho. 2001 Oct;28(11):1776-9. Japanese. PMID: 11708032 [PubMed - in process]

    Nakamura Y, Kamigaki T, Tamura T, Kunimoto Y, Habara K, Fukumoto S, Iwasaki T, Nakamura T, Ku Y, Kuroda Y.
    [Two cases of multiple liver metastases of colon cancer with systemic irinotecan and hepatic arterial injection of 5-FU].
    Gan To Kagaku Ryoho. 2001 Oct;28(11):1772-5. Japanese. PMID: 11708031 [PubMed - in process]

    Yukawa M, Ishikawa H, Nakayama T, Oshima S, Katsumoto Y, Furukawa J, Sue F, Inoue M.
    [Sigmoid colon cancer with multiple liver metastasis (H3) effectively treated with CPT-11 and DSM (degradable starch microsphere) HAI therapy and intensive high dosage 5-FU HAI therapy--a case report].
    Gan To Kagaku Ryoho. 2001 Oct;28(11):1763-7. Japanese. PMID: 11708029 [PubMed - in process]

    Yukawa N, Akaike M, Sugimasa Y, Takemiya S, Motohashi H.
    [Therapeutic strategy for hepatic metastasis of primary colon cancer].
    Gan To Kagaku Ryoho. 2001 Oct;28(11):1565-8. Japanese. PMID: 11707981 [PubMed - in process]

    Maruyama M, Toukairin Y, Baba H, Kure N, Nagahama T, Ebuchi M.
    [Pharmacokinetic study of the intraperitoneal administration of CPT-11 for patients with peritoneal seedings of gastric and colonic cancers].
    Gan To Kagaku Ryoho. 2001 Oct;28(11):1505-7. Japanese. PMID: 11707965 [PubMed - in process]

  6. ALTERNATIVE MEDICINE

    Hong J, Smith TJ, Ho CT, August DA, Yang CS.
    Effects of purified green and black tea polyphenols on cyclooxygenase- and lipoxygenase-dependent metabolism of arachidonic acid in human colon mucosa and colon tumor tissues.
    Biochem Pharmacol. 2001 Nov 1;62(9):1175-83. PMID: 11705450 [PubMed - in process]

    Nam KA, Kim S, Heo YH, Lee SK.
    Resveratrol analog, 3,5,2',4'-tetramethoxy-trans-stilbene, potentiates the inhibition of cell growth and induces apoptosis in human cancer cells.
    Arch Pharm Res. 2001 Oct;24(5):441-5. PMID: 11693548 [PubMed - in process]

    Berger SJ, Gupta S, Belfi CA, Gosky DM, Mukhtar H.
    Green tea constituent (-)-epigallocatechin-3-gallate inhibits topoisomerase i activity in human colon carcinoma cells.
    Biochem Biophys Res Commun. 2001 Oct 19;288(1):101-5. PMID: 11594758 [PubMed - in process]

    Oh YJ, Sung MK.
    Soybean saponins inhibit cell proliferation by suppressing PKC activation and induce differentiation of HT-29 human colon adenocarcinoma cells.
    Nutr Cancer. 2001;39(1):132-8. PMID: 11588895 [PubMed - in process]

    Gali-Muhtasib HU, Younes IH, Karchesy JJ, el-Sabban ME.
    Plant tannins inhibit the induction of aberrant crypt foci and colonic tumors by 1,2-dimethylhydrazine in mice.
    Nutr Cancer. 2001;39(1):108-16. PMID: 11588891 [PubMed - in process]

    Finley JW, Davis CD.
    Selenium (Se) from high-selenium broccoli is utilized differently than selenite, selenate and selenomethionine, but is more effective in inhibiting colon carcinogenesis.
    Biofactors. 2001;14(1-4):191-6. PMID: 11568456 [PubMed - indexed for MEDLINE]

    Goel A, Boland CR, Chauhan DP.
    Specific inhibition of cyclooxygenase-2 (COX-2) expression by dietary curcumin in HT-29 human colon cancer cells.
    Cancer Lett. 2001 Oct 30;172(2):111-8. PMID: 11566484 [PubMed - indexed for MEDLINE]

    >>>>>Sartippour MR, Liu C, Shao ZM, Go VL, Heber D, Nguyen M.
    Livistona extract inhibits angiogenesis and cancer growth.
    Oncol Rep. 2001 Nov-Dec;8(6):1355-7. PMID: 11605065 [PubMed - in process]

  7. DIET

    It ain't the fiber or lack thereof in the diet - It's the FAT which seems to cause the problem! Also, looks like there MIGHT be something to the well entrenched rumor in the alt med community that "sugar feeds cancer" - only it ain't the sugar, it's the INSULIN the body produces in response to the sugar that may cause the problem (see highlighted abstract)

    Nakaji S, Shimoyama T, Umeda T, Sakamoto J, Katsura S, Sugawara K, Baxter D.
    Dietary fiber showed no preventive effect against colon and rectal cancers in Japanese with low fat intake: an analysis from the results of nutrition surveys from 23 Japanese prefectures.
    BMC Cancer. 2001;1(1):14. PMID: 11701093 [PubMed - as supplied by publisher]

    Newmark HL, Yang K, Lipkin M, Kopelovich L, Liu Y, Fan K, Shinozaki H.
    A Western-style diet induces benign and malignant neoplasms in the colon of normal C57Bl/6 mice.
    Carcinogenesis. 2001 Nov;22(11):1871-5. PMID: 11698351 [PubMed - in process]

    Liu Z, Uesaka T, Watanabe H, Kato N.
    High fat diet enhances colonic cell proliferation and carcinogenesis in rats by elevating serum leptin. Int J Oncol. 2001 Nov;19(5):1009-14. PMID: 11605002 [PubMed - in process]

    Lund EK, Fairweather-Tait SJ, Wharf SG, Johnson IT.
    Chronic exposure to high levels of dietary iron fortification increases lipid peroxidation in the mucosa of the rat large intestine. J Nutr. 2001 Nov;131(11):2928-31. PMID: 11694620 [PubMed - in process]

    Davis CD, Johnson WT.
    Dietary copper and dimethylhydrazine affect protein kinase C isozyme protein and mRNA expression and the formation of aberrant crypts in colon of rats.
    Biofactors. 2001;15(1):11-26. PMID: 11673641 [PubMed - in process Jarvinen R, Knekt P, Hakulinen T, Aromaa A.
    Prospective study on milk products, calcium and cancers of the colon and rectum.
    Eur J Clin Nutr. 2001 Nov;55(11):1000-7. PMID: 11641750 [PubMed - in process]

    Slattery ML, Anderson K, Curtin K, Ma K, Schaffer D, Edwards S, Samowitz W.
    Lifestyle factors and Ki-ras mutations in colon cancer tumors.
    Mutat Res. 2001 Nov 1;483(1-2):73-81. PMID: 11600135 [PubMed - in process]

    Sesink AL, Termont DS, Kleibeuker JH, Van Der Meer R.
    Red meat and colon cancer: dietary haem-induced colonic cytotoxicity and epithelial hyperproliferation are inhibited by calcium.
    Carcinogenesis. 2001 Oct;22(10):1653-9. PMID: 11577005 [PubMed - in process]

    >>>>>Giovannucci E.
    Insulin, insulin-like growth factors and colon cancer: a review of the evidence.
    J Nutr. 2001 Nov;131(11):3109S-20S. PMID: 11694656 [PubMed - in process]

  8. HNPCC/Microsatellite Instability

    Samowitz WS, Curtin K, Lin HH, Robertson MA, Schaffer D, Nichols M, Gruenthal K, Leppert MF, Slattery ML.
    The colon cancer burden of genetically defined hereditary nonpolyposis colon cancer.
    Gastroenterology. 2001 Oct;121(4):830-8. PMID: 11606497 [PubMed - in process]

    Zhang S, Lloyd R, Bowden G, Glickman BW, de Boer JG.
    Msh2 DNA mismatch repair gene deficiency and the food-borne mutagen 2-amino-1-methy1-6-phenolimidazo [4,5-b] pyridine (PhIP) synergistically affect mutagenesis in mouse colon.
    Oncogene. 2001 Sep 20;20(42):6066-72. PMID: 11593414 [PubMed - indexed for MEDLINE]

    Percesepe A, Borghi F, Menigatti M, Losi L, Foroni M, Di Gregorio C, Rossi G, Pedroni M, Sala E, Vaccina F, Roncucci L, Benatti P, Viel A, Genuardi M, Marra G, Kristo P, Peltomaki P, Ponz de Leon M.
    Molecular screening for hereditary nonpolyposis colorectal cancer: a prospective, population-based study.
    J Clin Oncol. 2001 Oct 1;19(19):3944-50. PMID: 11579115 [PubMed - indexed for MEDLINE]

    Glaab WE, Hill RB, Skopek TR.
    Suppression of spontaneous and hydrogen peroxide-induced mutagenesis by the antioxidant ascorbate in mismatch repair-deficient human colon cancer cells.
    Carcinogenesis. 2001 Oct;22(10):1709-13. PMID: 11577013 [PubMed - in process]

    Wu AH, Shibata D, Yu MC, Lai MY, Ross RK.
    Dietary heterocyclic amines and microsatellite instability in colon adenocarcinomas.
    Carcinogenesis. 2001 Oct;22(10):1681-4. PMID: 11577009 [PubMed - in process]

    Hawkins NJ, Ward RL.
    Sporadic colorectal cancers with microsatellite instability and their possible origin in hyperplastic polyps and serrated adenomas.
    J Natl Cancer Inst. 2001 Sep 5;93(17):1307-13. PMID: 11535705 [PubMed - indexed for MEDLINE]

    Samowitz WS, Curtin K, Ma KN, Schaffer D, Coleman LW, Leppert M, Slattery ML.
    Microsatellite instability in sporadic colon cancer is associated with an improved prognosis at the population level.
    Cancer Epidemiol Biomarkers Prev. 2001 Sep;10(9):917-23. PMID: 11535541 [PubMed - indexed for MEDLINE]

  9. COLONOSCOPY

     Vos F, Serlie I, van Gelder R, Stoker J, Vrooman H, Post F.
    A review of technical advances in virtual colonoscopy.
    Medinfo. 2001;10(Pt 2):938-42. PMID: 11604871 [PubMed - in process]

  10. MISCELLANEOUS

     Leng SL, Leeding KS, Gibson PR, Bach LA.
    Insulin-like growth factor-II renders LIM 2405 human colon cancer cells resistant to butyrate-induced apoptosis: a potential mechanism for colon cancer cell survival in vivo.
    Carcinogenesis. 2001 Oct;22(10):1625-31. PMID: 11577001 [PubMed - in process]

    Labianca RF, Beretta GD, Pessi MA.
    Disease management considerations: disease management considerations.
    Drugs. 2001;61(12):1751-64. PMID: 11693464 [PubMed - in process]

    Borrelli F, Mereto E, Capasso F, Orsi P, Sini D, Izzo AA, Massa B, Boggio M, Mascolo N.
    Effect of bisacodyl and cascara on growth of aberrant crypt foci and malignant tumors in the rat colon.
    Life Sci. 2001 Sep 7;69(16):1871-7. PMID: 11693267 [PubMed - in process]

    Yamauchi K, Ogata Y, Nagase H, Shirouzu K.
    Inhibition of liver metastasis from orthotopically implanted colon cancer in nude mice by transfection of the TIMP-1 gene into KM12SM cells.
    Surg Today. 2001;31(9):791-8. PMID: 11686557 [PubMed - in process]

    Ogata Y, Miura K, Ohkita A, Nagase H, Shirouzu K.
    Imbalance between matrix metalloproteinase 9 and tissue inhibitor of metalloproteinases 1 expression by tumor cells implicated in liver metastasis from colorectal carcinoma.
    Kurume Med J. 2001;48(3):211-8. PMID: 11680936 [PubMed - in process]

    Marx J.
    Cancer research. New insights into metastasis.
    Science. 2001 Oct 12;294(5541):281-2. No abstract available. PMID: 11598274 [PubMed - indexed for MEDLINE]

    Kapiteijn E, Liefers GJ, Los LC, Kranenbarg EK, Hermans J, Tollenaar RA, Moriya Y, van de Velde CJ, van Krieken JH.
    Mechanisms of oncogenesis in colon versus rectal cancer.
    J Pathol. 2001 Sep;195(2):171-8. PMID: 11592095 [PubMed - indexed for MEDLINE]

    Goldstein NS, Armin M.
    Epidermal growth factor receptor immunohistochemical reactivity in patients with American Joint Committee on Cancer Stage IV colon adenocarcinoma: implications for a standardized scoring system.
    Cancer. 2001 Sep 1;92(5):1331-46. PMID: 11571750 [PubMed - indexed for MEDLINE]

    Witte D, Chirala M, Younes A, Li Y, Younes M.
    Estrogen receptor beta is expressed in human colorectal adenocarcinoma.
    Hum Pathol. 2001 Sep;32(9):940-4. PMID: 11567223 [PubMed - indexed for MEDLINE]

    Wallace HM, Caslake R.
    Polyamines and colon cancer.
    Eur J Gastroenterol Hepatol. 2001 Sep;13(9):1033-9. PMID: 11564951 [PubMed - in process]

    Horan AD, Koch CJ.
    The K(m) for Radiosensitization of Human Tumor Cells by Oxygen is Much Greater than 3 mmHg and is Further Increased by Elevated Levels of Cysteine.
    Radiat Res. 2001 Oct;156(4):388-98. PMID: 11554850 [PubMed - indexed for MEDLINE]