Home

    Quercetin

  1. 8/17/01 TITLE: Quercetin inhibits p21-RAS expression in human colon cancer cell lines and in primary colorectal tumors. SOURCE: Int J Cancer; 85(3):438-45 2000 UI: 20121925 AUTHOR: Ranelletti FO, Maggiano N, Serra FG, Ricci R, Larocca LM, Lanza P, Scambia G, Fattorossi A, Capelli A, Piantelli M Immunocytochemical studies have revealed that 10 microM quercetin reduced the steady state levels of p21-ras proteins in both colon cancer cell lines and primary colorectal tumors. These findings were confirmed by Western blot and flow cytometric analysis showing that the inhibition of p21-ras expression by quercetin was time- and concentration-dependent. Twenty-four-hour treatment with 10 microM quercetin reduced p21-ras levels to about 50% of control values. Quercetin was similarly effective in inhibiting the expression of K-, H-, and N-ras proteins. These effects of quercetin suggest a possible chemopreventive role for this compound in colorectal carcinogenesis

  2. 8/17/01 TITLE: Dietary quercetin, immune functions and colonic carcinogenesis in rats. AUTHOR: Exon JH, Magnuson BA, South EH, Hendrix K SOURCE: Immunopharmacol Immunotoxicol; 20(1):173-90 1998 UI: 98205289 Rats fed 100 mg/kg quercetin (QUE) daily for 7 weeks had significantly enhanced natural killer cell activity compared to their vehicle (VEH)-fed control... The distribution, multiplicity and total number of colonic preneoplastic lesions, aberrant crypt foci, was not significantly different in the QUE-fed azoxymethane-treated rats when compared to azoxymethane-treated vehicle-fed rats at the conclusion of 7 week feeding period. We found no correlation between immune function and development of preneoplastic colon lesions in this study.

  3. 8/17/01 Effects of Daily Oral Administration of Quercetin Chalcone and Modified Citrus Pectin on Implanted Colon-25 Tumor Growth in Balb-c Mice Altern Med Rev 2000;5(6):546-552. Adam Hayashi, MS, Aric C. Gillen, MS, and James R. Lott, PhD Two natural substances, quercetin (a flavonoid) and citrus pectin (a polysaccharide found in the cell wall of plants) are of particular interest to cancer researchers. Two modified versions of these substances - quercetin chalcone (QC) and a pH-modified citrus pectin (MCP) - are the focus of this study. Previous research has confirmed that quercetin exhibits antitumor properties, likely due to immune stimulation, free radical scavenging, alteration of the mitotic cycle in tumor cells, gene expression modification, anti-angiogenesis activity, or apoptosis induction, or a combination of these effects. MCP has inhibited metastases in animal studies of prostate cancer and melanoma

  4. 8/17/01 Quercetin abstrcts

  5. 9/10/01 TITLE: Inhibitory effects of green tea and grape juice on the phenol sulfotransferase activity of mouse intestines and human colon carcinoma cell line, Caco-2. AUTHOR: Tamura H, Matsui M SOURCE: Biol Pharm Bull; 23(6):695-9 2000 UI: 20320013 Among fruit juices examined (apple, grape, grapefruit and orange), grape juice exhibited the most potent inhibitory action on the P-ST activity of mouse intestines and human colon carcinoma cells. The inhibitory activity of grape juice was located mainly in the skin and seeds. Flavonols, such as quercetin and kaempferol, inhibited the P-ST activity at low concentrations

  6. 9/10/01 TITLE: Apoptosis cascade proteins are regulated in vivo by high intracolonic butyrate concentration: correlation with colon cancer inhibition. SOURCE: Oncol Res; 12(2):83-95 2000 UI: 21018977 AUTHOR: Avivi-Green C, Polak-Charcon S, Madar Z, Schwartz B The present study was aimed at evaluating the effect of high intracolonic butyrate concentrations, either through fermentation of a soluble fiber-enriched diet or via intracolonic butyrate instillation, on colon cancer in a chemically induced (dimethylhydrazine) rat model We conclude that high butyrate levels, either instilled or obtained following fermentation of soluble dietary fibers, inhibit early and late events in colon tumorigenesis by controlling the transcription expression and activity of key proteins involved in the apoptotic cascade.

  7. 9/10/01 TITLE: Phase I Study of PH-Modified Citrus Pectin (GBC-590) as an Intravenous (i.v.) 3-Hr Infusion Twice Weekly [times] 4 in Patients (pts) with Hormone-Refractory Prostate Cancer (HRPCa) (Meeting abstract). AUTHOR: Daliani D, Platt D, Bonnem E, Finn L, Logothetis C SOURCE: Proc Annu Meet Am Soc Clin Oncol; 18:A1294 1999 UI: 99701288 Conclusion: At current doses toxicity is minimal. Further dose escalation and PK studies are in progress. GBC-590 is one of the new class of antitumor agents; it's principal mechanism of antitumor activity is to inhibit invasion and metastasis and achieving the MTD may not be necessary for biologic activity. (C)

Home