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    Melatonin

  1. 3/15/02 Investigating Melatonin LEF Magazine, March 2002

  2. 9/24/01 Melatonin and RZR/ROR receptor ligand CGP 52608 induce apoptosis in the murine colonic cancer J Pineal Res 2001 Sep;31(2):179-82 Winczyk K, Pawlikowski M, Karasek M. This finding confirms our earlier observation that melatonin exerts a pro-apoptotic effect on murine colonic cancer cells. Moreover, because CGP 52608 is a ligand of RZR/ROR receptors and the latter are considered by some investigators as nuclear binding sites for melatonin, our data suggest the involvement of these receptors in the pro-apoptotic effect of melatonin.

  3. 9/24/01 Oncostatic activity of pineal neuroendocrine treatment with the pineal indoles melatonin and 5-methoxytryptamine in untreatable metastatic cancer patients progressing on melatonin alone. Neuroendocrinol Lett 2000;21(4):319-323 Lissoni P, Rovelli F, Frassineti A, Fumagalli L, Malysheva O, Conti A, Maestroni G. The study included 73 untreatable advanced solid tumor patients, who had progressed after two months of MLT therapy alone. According to tumor histotype, patients were randomized to receive MLT alone (20 mg/day orally in the evening) or MLT plus 5-MTT (1 mg at noon orally), every day for at least two months. The clinical response was evaluated according to WHO criteria. RESULTS: A partial response (PR) occurred in two patients treated with MLT + 5-MTT and in none of the patients receiving MLT alone. A stable disease (SD) was achieved in only 2/37 patients on MLT therapy alone, and in 8/36 patients receiving MLT plus 5-MTT. Therefore, the percent of non-progressing patients (SD + PR) obtained with MLT plus 5-MTT was significantly higher than that obtained with MLT alone.

  4. 9/24/01 Melatonin attenuates estradiol-induced oxidative damage to DNA: relevance for cancer prevention Exp Biol Med (Maywood) 2001 Jul;226(7):707-12 Karbownik M, Reiter RJ, Burkhardt S, Gitto E, Tan DX, Lewinski A. Melatonin had antioxidative actions in reducing oxidative damage to both DNA and to membrane lipids. Melatonin completely prevented the damaging action of E2 on DNA and synergized with the steroid to reduce lipid peroxidation.

  5. 9/24/01 Anticarcinogenic actions of melatonin which involve antioxidative processes: comparison with other antioxidants Int J Biochem Cell Biol 2001 Aug;33(8):735-53 Karbownik M, Lewinski A, Reiter RJ Among known antioxidants, melatonin has been an often investigated experimental agent in reducing cancer initiation and inhibiting the growth of established tumors. The indoleamine has been shown to protect macromolecules from oxidative mutilation induced by carcinogens. In these studies, a variety of in vitro and in vivo models were used and numerous indices of oxidative damage were evaluated. The protective effects of melatonin and several other indoleamine antioxidants against cellular damage caused by carcinogens make them potential supplements in the treatment or co-treatment at several stages of cancer.

  6. 9/24/01 The immunotherapeutic potential of melatonin. Expert Opin Investig Drugs 2001 Mar;10(3):467-76 Maestroni GJ. Through its pro-inflammatory action, MEL may play an adverse role in autoimmune diseases. Rheumatoid arthritis patients have increased nocturnal plasma levels of MEL and their synovial macrophages respond to MEL with an increased production of IL-12 and nitric oxide (NO). In these patients, inhibition of MEL synthesis or use of MEL antagonists might have a therapeutic effect. In other diseases such as multiple sclerosis the role of MEL is controversial. However, the correct therapeutic use of MEL or MEL antagonists should be based on a complete understanding of their mechanism of action. It is not yet clear whether MEL acts only on Th1 cells or also on T-helper Type 2 cells (Th2). This is an important point as the Th1/Th2 balance is of crucial importance in the immune system homeostasis

  7. 8/26/01 TITLE: Polyunsaturated fatty acids, melatonin, and cancer prevention. SOURCE: Biochem Pharmacol; 61(12):1455-62 2001 UI: 21271761 AUTHOR: Sauer LA, Dauchy RT, Blask DE Melatonin and n3 fatty acids acted via similar or identical G(i) protein-coupled signal transduction pathways, except that melatonin receptors and putative n3 fatty acid receptors were used. The results link the four factors in a common mechanism and provide new insights into the roles of dietary n6 and n3 polyunsaturated fatty acid intake, "light at night," and melatonin in cancer prevention in humans.

  8. 8/26/01 TITLE: Anti-angiogenic activity of melatonin in advanced cancer patients. SOURCE: Neuroendocrinol Lett; 22(1):45-7 2001 UI: 21234168 AUTHOR: Lissoni P, Rovelli F, Malugani F, Bucovec R, Conti A, Maestroni GJ Melatonin was given orally at 20 mg/day in the evening for at least 2 months. Serum levels of VEGF were measured by an enzyme immunoassay on venous blood samples collected at 15-day intervals. RESULTS: The clinical response consisted of minor response (MR) in 2, stable disease (SD) in 6 and progressive disease (PD) in the remaining 12 patients

  9. 8/26/01 TITLE: Melatonin and colon carcinogenesis. IV. Effect of melatonin on proliferative activity and expression of apoptosis-related proteins in the spleen of rats exposed to 1,2-dimethylhydrazine. SOURCE: Oncol Rep; 7(6):1401-5 2000 UI: 20491480 AUTHOR: Kossoy G, Ben-Hur H, Popovich I, Zabezhinski M, Anisimov V, Zusman I Therefore we conclude that anti-carcinogenic effects of melatonin are related to activation of several elements of the host's lymphatic system.

  10. 8/26/01 TITLE: Melatonin and colon carcinogenesis. III. Effect of melatonin on proliferative activity and apoptosis in colon mucosa and colon tumors induced by 1,2-dimethylhydrazine in rats. SOURCE: Exp Toxicol Pathol; 52(1):71-6 2000 UI: 20239426 AUTHOR: Anisimov VN, Popovich IG, Shtylik AV, Zabezhinski MA, Ben-Huh H, Gurevich P, Berman V, Tendler Y, Zusman I The multiplicity of colon tumors was also reduced in rats under the influence of melatonin. This effect is correlated with the significant inhibitory effect of the pineal hormone on mitotic index and with stimulating effect of melatonin on the relative number of apoptotic cells (TUNEL-method) in colon tumors. Long-term treatment with melatonin was followed also by the decrease in the area of lymphoid infiltrates in the colon mucosa of tumor-bearing rats.

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