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    Lactoferrin

    Bovine Lactoferrin is believed to have anticancer potential for colon, breast and other cancers.

  1. 9/9/01 Lactoferrin Update LEF Magazine

  2. 9/9/01 Lactoferrin: The Bioactive Peptide that Fights Disease LEF Magazine

  3. 9/9/01 Lactoferrin Source of Lactoferrin from LEF

  4. 9/9/01 Question about Lactoferrin (from CancerBackup.com, opposed to use)

  5. 9/9/01 Why Milk? UC Davis Magazine Online, Spring 2001

  6. 9/9/01 Involvement of Lactoferrin in Inflammatory Processes LABORATORY OF LIGAND-RECEPTOR INTERACTIONS

  7. 9/9/01 REVIEW: Lactoferrin and Its Biological Functions Received May 25, 2000; Revision received September 8, 2000 Lactoferrin is a unique polyfunctional protein that influences cell proliferation and differentiation. It can regulate granulopoiesis and DNA synthesis in some cells. Lactoferrin inhibits prostaglandin synthesis in human milk macrophages and activates the nonspecific immune response by stimulating phagocytosis and complement

  8. 9/24/01 Activation of intestinal mucosal immunity in tumor-bearing mice by lactoferrin Jpn J Cancer Res 2000 Oct;91(10):1022-7 Wang WP, Iigo M, Sato J, Sekine K, Adachi I, Tsuda H. We have previously demonstrated that oral administration of bovine lactoferrin (bLF) markedly increases CD4(+) and CD8(+) T cells and NK (asialoGM1(+) ) cells in the blood of tumor-bearing mice and enhances anti-metastatic activity. In this paper, we document that oral administration of bLF and bLF-hydrolysate (bLFH) is associated with strong increases in CD4(+) and CD8(+) T, as well as asialoGM1(+) cells in lymphoid tissues and lamina propria of the small intestine in mice, especially in tumor-bearing animals in which Co26Lu cells were implanted subcutaneously

  9. 9/24/01 Lactoferrin binds CpG-containing oligonucleotides and inhibits their immunostimulatory effects on human B cells J Immunol 2001 Sep 1;167(5):2921-8 Britigan BE, Lewis TS, Waldschmidt M, McCormick ML, Krieg AM. Unmethylated CpG dinucleotide motifs in bacterial DNA, as well as oligodeoxynucleotides (ODN) containing these motifs, are potent stimuli for many host immunological responses. These CpG motifs may enhance host responses to bacterial infection and are being examined as immune activators for therapeutic applications in cancer, allergy/asthma, and infectious diseases. However, little attention has been given to processes that down-modulate this response Lactoferrin binding of CpG-containing ODN may serve to modulate and terminate host response to these potent immunostimulatory molecules at mucosal surfaces and sites of bacterial infection

  10. 9/9/01 TITLE: Prevention of colon carcinogenesis and carcinoma metastasis by orally administered bovine lactoferrin in animals SOURCE: Biofactors; 12(1-4):83-8 2000 UI: 21084226 AUTHOR: Tsuda H, Sekine K, Takasuka N, Toriyama-Baba H, Iigo M Bovine lactoferrin (bLF), a milk protein known to have bacteriostatic properties was examined for its preventive effects on colon and other organ carcinogenesis and experimental metastasis Results of those experiments indicate that bLF remarkably prevents colon carcinogenesis and lung metastasis of colon carcinoma cells, possibly due to increasing cytotoxic cells in the peripheral blood.

  11. 9/9/01 TITLE: Orally administered bovine lactoferrin systemically inhibits VEGF(165)-mediated angiogenesis in the rat. AUTHOR: Norrby K, Mattsby-Baltzer I, Innocenti M, Tuneberg S SOURCE: Int J Cancer; 91(2):236-40 2001 UI: 20581963 Lactoferrin (Lf) systemically suppresses tumor growth and metastasis by unknown mechanisms. We have studied the effect of orally administered iron-unsaturated bovine Lf on angiogenesis induced by VEGF(165) and IL-1-alpha in adult rats using the mesenteric-window angiogenesis assay. VEGF(165) is a major angiogenic factor in most, if not all, tumors and other angiogenesis diseases of clinical relevance. A number of objective angiogenesis variables were analyzed using microscopic morphometry and image analysis. Lf treatment significantly inhibited the VEGF(165)-mediated response in terms of microvessel spatial extension, overall vascularity and incidence of crossover

  12. 9/9/01 TITLE: Activation of intestinal mucosal immunity in tumor-bearing mice by lactoferrin AUTHOR: Wang WP, Iigo M, Sato J, Sekine K, Adachi I, Tsuda H SOURCE: Jpn J Cancer Res; 91(10):1022-7 2000 UI: 20504290 We have previously demonstrated that oral administration of bovine lactoferrin (bLF) markedly increases CD4(+) and CD8(+) T cells and NK (asialoGM1(+) ) cells in the blood of tumor-bearing mice and enhances anti-metastatic activity. In this paper, we document that oral administration of bLF and bLF-hydrolysate (bLFH) is associated with strong increases in CD4(+) and CD8(+) T, as well as asialoGM1(+) cells in lymphoid tissues and lamina propria of the small intestine in mice, especially in tumor-bearing animals in which Co26Lu cells were implanted subcutaneously

  13. 9/9/01 TITLE: Inhibitory effects of bovine lactoferrin on colon carcinoma 26 lung metastasis in mice SOURCE: Clin Exp Metastasis; 17(1):35-40 1999 UI: 99317033 AUTHOR: Iigo M, Kuhara T, Ushida Y, Sekine K, Moore MA, Tsuda H In order to determine the effects of the multifunctional iron-binding glycoprotein, lactoferrin (LF), and related compounds on tumor growth and metastasis, bovine LF (bLF), and bLF hydrolysate and lactoferricin (bLFcin), active products generated by acid-pepsin hydrolysis were administered orally to BALB/c mice bearing subcutaneous (s.c.) implants of the highly metastatic colon carcinoma 26 (Co 26Lu). bLF and the bLF hydrolysate demonstrated significant inhibition of lung metastatic colony formation from s.c. implanted tumors without appreciable effects on tumor growth. bLFcin displayed a tendency for inhibition of lung metastasis

  14. 9/9/01 TITLE: Possible chemopreventive effects of bovine lactoferrin on esophagus and lung carcinogenesis in the rat. SOURCE: Jpn J Cancer Res; 90(3):262-7 1999 UI: 99285534 AUTHOR: Ushida Y, Sekine K, Kuhara T, Takasuka N, Iigo M, Maeda M, Tsuda H A milk component, bovine lactoferrin (bLF), previously shown by us to be a strong chemopreventive of colon carcinoma development, was examined for its influence on other organs using a rat multi-organ carcinogenesis model.

  15. 9/9/01 TITLE: Bovine lactoferrin and Lactoferricin inhibit tumor metastasis in mice. AUTHOR: Yoo YC, Watanabe S, Watanabe R, Hata K, Shimazaki K, Azuma I SOURCE: Adv Exp Med Biol; 443:285-91 1998 UI: 98454656 The effect of a bovine milk protein, lactoferrin (bLf), and a pepsin-generated peptide of bLf, lactoferricin (Lfcin-B), on inhibition of tumor metastasis produced by highly metastatic murine tumor cells, B16-BL6 melanoma and L5178Y-ML25 lymphoma cells, was examined in experimental and spontaneous metastasis models using syngeneic mice In spontaneous metastasis model, multiple administration of both apo-bLf and Lfcin-B significantly inhibited lung metastasis of B16-BL6 cells, however it was only apo-bLf that exhibited the inhibitory effect of tumor growth at the time of primary tumor amputation (on day 21) after tumor inoculation. The results suggest that apo-bLf and Lfcin-B inhibit tumor metastasis through different mechanisms, and that the inhibitory activity of bLf on tumor metastasis may be related to the property of iron (Fe3+)-saturation.

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