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    Ginseng

  1. 9/10/01 Panax Ginseng from HerbMed

  2. 10/27/01 Ginseng People's Pharmacy Herb Library

  3. 9/10/01 TITLE: In vitro inhibitory effect of protopanaxadiol ginsenosides on tumor necrosis factor (TNF)-alpha production and its modulation by known TNF-alpha antagonists. AUTHOR: Cho JY, Yoo ES, Baik KU, Park MH, Han BH SOURCE: Planta Med; 67(3):213-8 2001 UI: 21243825 These data suggest that PPDGs may possess potential therapeutic efficacy against TNF-alpha mediated disease and the therapeutic potency of PPDGs may be enhanced when co-treated with various kinds of known TNF-alpha antagonists but not with cAMP PDE inhibitors.

  4. 9/10/01 TITLE: Induction of apoptosis by a novel intestinal metabolite of ginseng saponin via cytochrome c-mediated activation of caspase-3 protease. AUTHOR: Lee SJ, Ko WG, Kim JH, Sung JH, Moon CK, Lee BH SOURCE: Biochem Pharmacol; 60(5):677-85 2000 UI: 20386914 Ginseng saponins exert various important pharmacological effects with regard to the control of many diseases including cancer. The novel intestinal bacterial metabolites of ginseng protopanaxadiol saponins have recently been found and isolated after the oral administration of ginseng extract in human and rats

  5. 9/10/01 TITLE: Anti-proliferative effect of ginseng saponins on human prostate cancer cell line. AUTHOR: Liu WK, Xu SX, Che CT SOURCE: Life Sci; 67(11):1297-306 2000 UI: 20426014 . Taken our results together, we suggested that ginsenoside Rg3 activated the expression of cyclin-kinase inhibitors, p21 and p27, arrested LNCaP cells at G1 phase, and subsequently inhibited cell growth through a caspase3-mediated apoptosis mechanism.

  6. 9/10/01 TITLE: The cancer-preventive potential of Panax ginseng: a review of human and experimental evidence. SOURCE: Cancer Causes Control; 11(6):565-76 2000 UI: 20336386 AUTHOR: Shin HR, Kim JY, Yun TK, Morgan G, Vainio H CONCLUSION: While Panax ginseng C. A. Meyer has shown cancer-preventive effects both in experimental models and in epidemiological studies, the evidence is currently not conclusive as to its cancer-preventive activity in humans. The available evidence warrants further research into the possible role of ginseng in the prevention of human cancer and carcinogenesis.

  7. 9/10/01 TITLE: Inhibition by ginseng of 1,2-dimethylhydrazine induction of aberrant crypt foci in the rat colon. SOURCE: Nutr Cancer; 36(1):66-73 2000 UI: 20258553 AUTHOR: Li W, Wanibuchi H, Salim EI, Wei M, Yamamoto S, Nishino H, Fukushima S These findings suggest that dietary administration of red ginseng in combination with DMH suppresses colon carcinogenesis of rats, and the inhibition may be associated, in part, with suppression of cell proliferation in the colonic mucosa.

  8. 9/10/01 TITLE: Antitumor activity of a novel ginseng saponin metabolite in human pulmonary adenocarcinoma cells resistant to cisplatin. AUTHOR: Lee SJ, Sung JH, Lee SJ, Moon CK, Lee BH SOURCE: Cancer Lett; 144(1):39-43 1999 UI: 99431201

  9. 9/10/01 TITLE: Anti-proliferating effects of ginsenoside Rh2 on MCF-7 human breast cancer cells AUTHOR: Oh M, Choi YH, Choi S, Chung H, Kim K, Kim SI, Kim DK, Kim ND SOURCE: Int J Oncol; 14(5):869-75 1999 UI: 99218366 Ginsenoside Rh2 (G-Rh2) isolated from the root of Panax ginseng has been shown to have anti-cancer proliferation, differentiation and chemopreventive effects in certain cancer cell types. We investigated the mechanism of G-Rh2-induced growth inhibition in MCF-7 human breast carcinoma cells. G-Rh2 significantly inhibited the cell growth in a concentration-dependent manner, which effect was reversible, and induced a G1 arrest in cell cycle progression

  10. 9/10/01 TITLE: The effects of ginseng radix rubra on human vascular endothelial cells. SOURCE: Am J Chin Med; 26(3-4):365-73 1998 UI: 99079017 AUTHOR: Nakajima S, Uchiyama Y, Yoshida K, Mizukawa H, Haruki E The effect of Ginseng Radix Rubra (Red ginseng) on human vascular endothelial cells was examined. Red ginseng was found to promote the proliferation of vascular endothelial cells, inhibit the production but promote the decomposition of endothelin, which is known to constrict blood vessels and raise blood pressure as well as accelerated the synthesis of nitric oxide, which is known to have an angio-tonic effect. Furthermore, Red ginseng was observed to increase the production of Interleukin 1 beta, which is known to play important roles in the homeostatic activities of the human body such as immunity and inflammation as well as increasing the production of tissue plasminogen activators, which suppress the formation of thrombin in the blood coagulation and fibrinolysis mechanisms. It is suggested that Red ginseng has the effect of accelerating endothelial cells proliferation and of promoting physiological activities.

  11. 9/10/01 TITLE: Cancer chemopreventive and therapeutic activities of red ginseng. AUTHOR: Xiaoguang C, Hongyan L, Xiaohong L, Zhaodi F, Yan L, Lihua T, Rui H SOURCE: J Ethnopharmacol; 60(1):71-8 1998 UI: 98192104 This suggests that red ginseng extracts have potent tumor therapeutic activity and improve the cell immune system.

  12. 9/10/01 TITLE: Asian studies of cancer chemoprevention: latest clinical results. AUTHOR: Kakizoe T SOURCE: Eur J Cancer; 36(10):1303-9 2000 UI: 20340785 In Korea, ginseng is the main focus of studies of chemopreventive agents. A large body of information has been collected and prospective studies are also ongoing

  13. 9/10/01 TITLE: Inhibition by ginseng of 1,2-dimethylhydrazine induction of aberrant crypt foci in the rat colon. AUTHOR: Li W, Wanibuchi H, Salim EI, Wei M, Yamamoto S, Nishino H, Fukushima S SOURCE: Nutr Cancer; 36(1):66-73 2000 UI: 20258553 These findings suggest that dietary administration of red ginseng in combination with DMH suppresses colon carcinogenesis of rats, and the inhibition may be associated, in part, with suppression of cell proliferation in the colonic mucosa.

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