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Last Updated 9/16/02

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Contents

  1. Overview
  2. Searches on Experimental and Unconventional Board
  3. News
  4. General Info
  5. Diet
  6. Organizations
  7. Journals
  8. Life Extension Foundation
  9. Books
  10. Herbal Reference
  11. Sources of Herbs
  12. Bulletin Board Posts of Interest
  13. Chemoprevention
  14. More on Theory of Chemoprevention
  15. Arthritis/Ulcerative Colitis
  16. Miscellaneous

    Herbs and Natural Substances

  17. Amino Acids
  18. Antioxidants
  19. Berberine
  20. Baikal Skullcap
  21. Boswellia
  22. Bromelain
  23. Butcher's Broom
  24. Cat's Claw
  25. Cayenne
  26. Celebrex
  27. Chinese Herbs (miscellaneous)
  28. Chamomile
  29. Cimetidine (Tagamet)
  30. Citrus Derivatives
  31. Conjugated Linoleic Acid
  32. Curcumin
  33. Devil's Claw
  34. Feverfew
  35. Fish Oil (Omega 3 Fatty Acids)
  36. Garlic
  37. Ginger
  38. Ginseng
  39. Ginko Biloba
  40. Glutamine
  41. Green Tea
  42. Guggul
  43. HolyBasil
  44. Lactoferrin
  45. Licorice
  46. Lovastatin
  47. Low Dose Chemotherapy
  48. Melatonin
  49. Milk Thistle
  50. Miscellaneous
  51. Myrrh
  52. Naltrexone
  53. Nettle
  54. Olive Leaf
  55. Oltipraz
  56. Oregano
  57. PSK - Maitake Mushrooms
  58. Propolis
  59. Quercetin
  60. Resveratrol
  61. Retinoic Acid
  62. Rosemary
  63. Selenium
  64. Shark Liver Oil
  65. Soy (Genestein)
  66. SPES
  67. Squalene (in Dietary Olive Oil)
  68. Whey
  69. Willow Bark
  70. Wobenzym

    Overview

  1. 8/26/02 Fighting Cancer With Food Natural COX-2 Inhibitors

  2. 7/20/02 Phytonutrients and Phytochemicals Good list of different classes - potentially useful in cancer chemoprevention

  3. 6/5/02 Chemoprevention of Cancer Scientific American 1996

  4. 6/1/02 Complementary and Alternative Medicine in the Treatment of Cancer: Current Research and Future Directions Oncology Issues 15(6):17-19, 2000 FULL TEXT

  5. 9/9/01 TITLE: Current prospects for controlling cancer growth with non-cytotoxic agents--nutrients, phytochemicals, herbal extracts, and available drugs. SOURCE: Med Hypotheses; 56(2):137-54 2001 UI: 21323887 AUTHOR: McCarty MF In animal or cell culture studies, the growth and spread of cancer can be slowed by many nutrients, food factors, herbal extracts, and well-tolerated, available drugs that are still rarely used in the clinical management of cancer, in part because they seem unlikely to constitute definitive therapies in themselves. However, it is reasonable to expect that mechanistically complementary combinations of these measures could have a worthwhile impact on survival times and, when used as adjuvants, could improve the cure rates achievable with standard therapies. The therapeutic options available in this regard include measures that: down-regulate serum free IGF-I; suppress the synthesis of mevalonic acid and/or certain derivatives thereof; modulate arachidonate metabolism by inhibiting 5-lipoxygenase, 12-lipoxygenase, or COX-2; antagonize the activation of AP-1 transcription factors; promote the activation of PPAR-gamma transcription factors; and that suppress angiogenesis by additional mechanisms. Many of these measures appear suitable for use in cancer prevention.

  6. 8/23/01 TITLE: Approaches for chronic disease prevention based on current understanding of underlying mechanisms. AUTHOR: Weisburger JH SOURCE: Am J Clin Nutr; 71(6 Suppl):1710S-4S; discussion 1715S-9S 2000 UI: 20298230 Fish-eating populations have lower incidences of heart disease and of many types of cancers than do other populations, which may be the result of the n-3 polyunsaturated oils found in fish. Among other dietary practices that may reduce the risk of cancer and cardiovascular disease are consuming 5-9 servings of fruits and vegetables daily, which provides antioxidants such as quercetin and isothiocyanates; having a high fiber intake, including bran cereal; and drinking 1.5-2.5 L of fluids daily. Tea polyphenols found in black and green tea may have a protective effect against heart disease and some cancers

  7. 8/17/01 TITLE: Progress in cancer chemoprevention: development of diet-derived chemopreventive agents. AUTHOR: Kelloff GJ, Crowell JA, Steele VE, Lubet RA, Malone WA, Boone CW, Kopelovich L, Hawk ET, Lieberman R, Lawrence JA, Ali I, Viner JL, Sigman CC SOURCE: J Nutr; 130(2S Suppl):467S-471S 2000 UI: 20185006 . Numerous diet-derived agents are included among the >40 promising agents and agent combinations that are being evaluated clinically as chemopreventive agents for major cancer targets including breast, prostate, colon and lung. Examples include green and black tea polyphenols, soy isoflavones, Bowman-Birk soy protease inhibitor, curcumin, phenethyl isothiocyanate, sulforaphane, lycopene, indole-3-carbinol, perillyl alcohol, vitamin D, vitamin E, selenium and calcium

  8. 8/26/01 TITLE: Health-promoting properties of common herbs. AUTHOR: Craig WJ SOURCE: Am J Clin Nutr; 70(3 Suppl):491S-499S 1999 UI: 99408686 Research interest has focused on various herbs that possess hypolipidemic, antiplatelet, antitumor, or immune-stimulating properties that may be useful adjuncts in helping reduce the risk of cardiovascular disease and cancer. In different herbs, a wide variety of active phytochemicals, including the flavonoids, terpenoids, lignans, sulfides, polyphenolics, carotenoids, coumarins, saponins, plant sterols, curcumins, and phthalides have been identified Many of these herbs contain potent antioxidant compounds that provide significant protection against chronic diseases. These compounds may protect LDL cholesterol from oxidation, inhibit cyclooxygenase and lipoxygenase enzymes, inhibit lipid peroxidation, or have antiviral or antitumor activity

  9. 10/3/01 MOST PROMOSING HERBAL THERAPIES CENTER FOR MIND-BODY MEDICINE COMPREHENSIVE CANCER CARE 2000 Presenters: Ralph Moss, PhD and Mark Blumenthal

  10. 2/1/02 Herbal Therapies for Cancer By Vivekan Don Flint and Michael Lerner Research Assistance: Melanie Smith October, 1997

  11. 4/21/01 Dr. Weil: Chemo OK, but other treatments needed CNN News. Larry King, Dr. Weil, Alternative Medicine, Suzanne Somers, Iscador(herbal)

  12. 7/19/01 Testimony of Dean Ornish, M.D. Subcommittee on Labor, Health and Human Services, and Education Committee on Appropriations United States Senate Hearing on Complementary, Alternative, and Mind/Body Medicine March 28, 2000

  13. 2/3/02 Synergy and other interactions in phytomedicines Phytomedicine 2001 Sep;8(5):401-9 PMID: 11695885 Synergistic interactions are of vital importance in phytomedicines, to explain difficulties in always isolating a single active ingredient, and explain the efficacy of apparently low doses of active constituents in a herbal product. This concept, that a whole or partially purified extract of a plant offers advantages over a single isolated ingredient, also underpins the philosophy of herbal medicine. Evidence to support the occurrence of synergy in within phytomedicines is now accumulating and is reviewed here

  14. 2/3/02 The role of phytosterols and phytosterolins in immune modulation: a review of the past 10 years. Curr Opin Clin Nutr Metab Care 2001 Nov;4(6):471-5 PMID: 11706278 Although plant sterols (phytosterols) were chemically described in 1922, their biological role in human and animal health has been underestimated. Their ability to control cholesterol plasma levels in hypercholesterolimic patients was first described in 1983 when the structure of phytosterols implied that they could, by steric hindrance, inhibit the absorption of cholesterol from our diets. This has led to the development of functional foods containing high contents of these plant molecules or their esters as cholesterol controlling foods. Over the last 15 years, however, several reports have appeared in the literature indicating that phytosterols have some immunological activity as highlighted in animal models of inflammation or even in in-vitro and in-vivo models of cancer (colorectal and breast cancer).

  15. 6/1/02 Natural Products to Support Chemotherapy Dr. Murray Online

  16. 6/1/02 An Integrated Alternative Medicine Program Oncology Issues 15(6):14-15, 2000

  17. 7/25/02 Steve Dunn's Alternative Therapies Page

    Searches of Interest From Experimental and Unconventional

  18. 6/5/02 Cimetidine (Tagamet)

  19. 6/5/02 Oltipraz

  20. 6/5/02 PSK

  21. 6/5/02 Resveratrol

  22. 6/5/02 Curcumin

  23. 6/5/02 Green Tea

  24. 6/5/02 Lactoferrin

    News

  25. 7/31/02 LEF News -- LEF News Archive

  26. 2/3/02 Intelihealth CAM News

  27. 8/2/02 Ralph Moss Newsletter

  28. 8/2/02 Dr. Mercola's Newsletter

  29. 1/30/02 Natural Health Check Alt med news

  30. 8/12/01 News About Complementary & Alternative Medicine (Cancerpage.com)

  31. 4/17/01 News About Complementary & Alternative Medicine (qualitycounts.com)

  32. 11/09/01 Alternative Medicine for Cancer Patients News, Articles, etc.

  33. 1/21/02 HerbWorld News Online

  34. 2/2/02 COX-2 Inhibitor News (qualitycounts.com)

  35. 6/10/02 Medline Plus Alt Med includes news section

    General Info on Alt Med

  36. 11/06/01 Office of Technology Assessment:Unconventional Cancer Treatments (1990) Online Book

  37. 6/3/01 NCI Summary of Alternative Therapies

  38. 1/19/02 MD Anderson Review of Alternative Therapies

  39. 2/1/02 University of Pittsburgh Alt Med Homepage

  40. 2/3/02 Intelihealth CAM Harvard Medical School. Lots of info here - articles, herb encyclopedia, etc.

  41. 1/7/02 CAM - including good herb list - from American Cancer Society

  42. 5/01/01 Unconventional Cancer Therapies - BC Cancer Agency (Canadian) List of Alternative Therapies and Descriptions

  43. 9/10/01 An Overview of "Alternative" Methods From Quackwatch.com (opposed to alt med)

  44. 6/5/02 Alternative and Complementary Medicine From Arlene Harder's Learning Place Online

  45. 6/5/02 Alternative Therapy Critics and Skeptics From Arlene Harder's Learning Place Online

  46. 6/5/02 When Alternative Practitioners Promise More than They Deliver From Arlene Harder's Learning Place Online

  47. 1/21/02 Alternative Medicine - People

  48. 1/21/02 Alternativemedicine.com

  49. 1/21/02 Office of Dietary Supplements (govt)

  50. 1/21/02 McMaster Alternative Medicine Site

  51. 1/21/02 Alternative Cancer Therapies FAQ

  52. 2/1/02 Unconventional therapies for cancer Canadian Medical Association Journal

  53. 2/1/02 Healthcare Reality Check Science-based Information on Alternative and Complementary Medicine

  54. 2/1/02 Research Database -International Updates Herbal Medicine

  55. 2/3/02 The Holistic Channel

  56. 6/10/01 Annieappleseedproject Alternative Therapy Site

  57. 6/22/01 CancerOption.com Alternative therapy site "Supported by doctors and oncologists, CancerOption.com, Inc. has developed specific complementary therapies that assist in the prevention and reoccurrence of cancers"

  58. 5/5/02 Holistic Online

  59. 5/8/02 Yahoo Health Alternative Medicine

  60. 9/1/02 BJM Complementary Medicine

    Diet/Nutrition

  61. 11/24/02 Two Dietary Regimes for Cancer - Macrobiotics and Gerson

  62. 9/6/02 Nutrition and Cancer A paper by A.B. Robinson is available at this website which reports the results of an experiment on dietary restriction in mice to control cancer growth

  63. 9/17/01 Beating Cancer With Nutrition Book by Dr. Patrick Quillin

  64. 2/1/02 Nutritional Medicine Patrick Quillin, Ph.D., R.D. Elson Haas, M.D. Richard A. Passwater Ph. D. Charles Simone, M.D.

  65. 9/13/01 Dietary Supplements for Support During Cancer

  66. 9/13/01 How to fight cancer by using your fork

  67. 9/1/01 Cancer's Sweet Tooth From The April 2000 Issue of Nutrition Science News

  68. 9/1/01 What to Eat / Supplement if One Has Cancer

  69. 7/19/01 Nutrition and Cancer: An Update ASCO 2001

  70. 6/2/2001 Colon Cancer Panel Discussion This panel focused on complementary therapies to prevent and treat colon cancer. The panel reviewed the evidence on dietary influences and the use of supplements and herbal therapies. Programs for making complementary and alternative therapies an integral part of comprehensive care for colon cancer were outlined. Dr. Nixon spoke about supplements. Dr. Nixon works in a cancer prevention research laboratory with outreach, clinical, and epidemiological components which relate to colon cancer. He stressed colon cancer prevention and treatment. Dr. Wargovich talked about research aspects of colon cancer prevention, the use of cylooxygenase (COX) inhibitors, herbs and diet. Patients with colon polyps or colon cancer are encouraged to increase fiber intake, decrease fat intake, exercise more and possibly supplement it with pharmacological agents such as cyclooxygenase inhibitors.

  71. 10/2/01 DNA damage from micronutrient deficiencies is likely to be a major cause of cancer Mutat Res 2001 Apr 18;475(1-2):7-20 Ames BN. A deficiency of any of the micronutrients: folic acid, Vitamin B12, Vitamin B6, niacin, Vitamin C, Vitamin E, iron, or zinc, mimics radiation in damaging DNA by causing single- and double-strand breaks, oxidative lesions, or both

  72. 10/3/01 Micronutrient Supplementation for Patients With Metastatic Cancer Medscape (free registration required) The optimal content for a program of micronutrient supplementation is unknown. After much discussion, the combination of micronutrients, chosen empirically, is as follows: a high-potency multivitamin (2 capsules twice a day), calcium ascorbate (vitamin C, 4 g twice a day), mixed natural carotenoids standardized to -carotene (30 mg twice a day), and d--tocopheryl succinate (vitamin E, 400 IU twice a day). The combination will be administered as several different commercially available preparations

  73. 7/7/01 Nutrition and Colon Cancer Prevention

  74. 9/13/01 Practical Prevention of Colon Cancer

  75. 7/19/01 Research Summary: A Look at Sulforaphane Glucosinolate (SGS(tm)) and Preliminary Evidence for Its Role in Reducing Risk of Cancer Johns Hopkins University Study Shows Some Broccoli Sprout Varieties to Have 20 to 50 times More SGS than Mature, Cooked Broccoli

  76. 6/7/01 TITLE: Inhibition of azoxymethane-induced colon cancer by orange juice. AUTHOR: Miyagi Y, Om AS, Chee KM, Bennink MR SOURCE: Nutr Cancer; 36(2):224-9 2000 UI: 20348510

  77. 6/5/02 Study Touts Broccoli to Fight Ulcers, Cancer Tuesday, May 28, 2002; Page A04 Subsequent studies found that sulforaphane could prevent the development of breast and colon cancer, as well as other tumors, in mice. Then Talalay's team found that the key protective compound in broccoli (a chemical called glucoraphanin, which the body turns into sulforaphane) is at least 20 times more concentrated in three-day-old broccoli sprouts than it is in broccoli.

  78. 6/5/02 Black Raspberries A Potentially Powerful Agent In Fight Against Colon Cancer “The results of this study would translate in humans to eating two large bowls -- or four cups -- of fresh black raspberries each day,” he said. “That may seem a bit extreme. People need to know that these animals are given whopping doses of a carcinogen. It’s conceivable that a much lower dose would be effective in humans.”

  79. 6/5/02 Fruits, vegetables and whole grains slow the growth of tumor compounds Elson has been studying compounds he calls isoprenoids, a group that includes more than 22,000 compounds. All are derived from a parent compound called mevalonic acid. Limonene and lycopene are examples of isoprenoids that inhibit cancer. Many isoprenoids contribute to plants' distinctive flavors and fragrances, Elson says. In plants, isoprenoids help regulate germination, growth, flowering, and dormancy while attracting pollinators and protecting plants from insects and fungi. Elson began working with isoprenoids because some can reduce cholesterol levels in animals. Initially he hoped that depriving tumor cells of cholesterol would make them susceptible to cancer treatments. But Elson's early experiments showed he could not lower the cholesterol in tumor cells by feeding animals isoprenoids. However, he noticed that the isoprenoids slowed tumor growth. To screen isoprenoids for those with anticarcinogenic activity, Elson tests them against a cell line developed from an extremely aggressive form of mouse melanoma. He has identified many isoprenoids that can slow the growth of this cell line. The tricky part has been finding isoprenoids that suppress cancer growth at the low concentrations that might occur in diets.

  80. 6/5/02 Spirulina Anti-Cancer Studies

  81. 6/5/02 Avocado.org New research indicates that the California avocado, one of nature's functional foods, contains phytochemicals that may help fight chronic illnesses, such as heart disease and cancer. The phytochemical profile of the California avocado includes a cholesterol-lowering phytosterol called beta-sitosterol and the antioxidant glutathione, according to Dr. David Heber, director of the UCLA Center for Human Nutrition. Evidence suggests phytosterol and glutathione may help prevent certain types of cancers and heart disease in humans.

  82. 6/5/02 The avocado advantage August 15, 2000 The avocado's image first took on some polish with a 1996 study by researchers at the Instituto Mexicano del Seguro Social in Mexico (Archives of Medical Research, Winter 1996) that looked at the health benefits of daily avocado consumption. The 45 volunteers who ate avocados every day for a week experienced an average 17 percent drop in total blood cholesterol. Their cholesterol ratio also changed in a healthy way: Their levels of LDL (low-density lipoprotein, or "bad fat") and triglycerides, both associated with heart disease, went down. Their HDL (high-density lipoprotein, or "good fat") levels, which tend to lower the risk of heart disease, climbed.

    Organizations

  83. 5/3/01 Steven Barrett's Quackwatch (opposed to alt med)

  84. 9/10/01 Canadian Quackery Watch (opposed to alt med)

  85. 8/26/01 Haelth Alternative Medicine Clinic, chaired by Dr. William Fair

  86. 9/17/01 Cancer Treatment Centers of America Cancer Treatment Centers of America uses a multi-modality approach to treat cancer. That simply means we combine traditional therapies, primarily surgery, radiation and chemotherapy (including fractionated dose), with medicine's newest therapies such as biological therapy and immunotherapy.

  87. 9/24/01 Consumerlab.com Testing of Herbal products for purity and potency.

  88. 9/10/01 Alternative Medicine Foundation Publishes JOURNAL OF ALTERNATIVE AND COMPLEMENTARY MEDICINE. Mission Statement: The Alternative Medicine Foundation is a 501(c)(3) nonprofit tax exempt organization formed to provide: * evidence-based research resources for health care professionals * responsible and reliable information for patients and consumers about the integration of alternative and conventional medicine

  89. 2/5/02 American Neutraceutical Assn. Journal, Abstracts, News, etc.

  90. 8/26/02 Cancer Cure Foundation has list of alternative clinics

  91. 8/26/02 Block Medical Center

    Journals/Conferences

  92. 10/3/01 Nutrition and Cancer Journal Medscape (free registration required) Free online articles

  93. 8/17/01 Alternative Medicine Review

  94. 9/24/01 Comprehensive Cancer Care Conference Transcripts of talks from past conferences

  95. 8/19/01 Life Extension Foundation Magazine Archives

    Life Extension Foundation

  96. 2/2/02 LEF Main Website

  97. 7/7/01 CANCER (ADJUVANT) TREATMENT Life Exension Foundation Article

  98. 2/2/02 Cancer Radiation Therapy

  99. 2/2/02 Cancer Surgery

  100. 2/2/02 Cancer Chemotherapy

  101. 2/2/02 Alternative Treatments for Cancer

  102. 2/2/02 Pnacreatic Cancer Many of the therapies here are applicable to Colon Cancer as well.

  103. 2/2/02 Catabolic Wasting

  104. 8/19/01 Life Extension Foundation Magazine Archives

    Books

  105. 1/7/02 BEYOND ASPIRIN Book Review 1 -- Book Review 2 -- Book Review 3

  106. 1/19/02 NATURAL COMPOUNDS IN CANCER THERAPY Book Review 1 -- Book Review 2 ompress.com list of compounds discussed

  107. 1/19/02 Cancer Increasing your odds for survival Book

  108. 2/14/02 Office of Technology Assessments - Unconventional Cancer Treatments FREE Online Book (1990)

  109. 2/14/02 The Medical Messiahs - A Social History of Health Quackery in Twentieth Century America FREE Online Book (1966)

  110. 3/24/02 Principles and Practice of Phytotherapy: Modern Herbal Medicine Book Review (from Alt Med Review)

  111. 5/10/02 Prescription for Herbal Healing: An Easy-to-Use A-Z Reference to Hundreds of Common Disorders and Their Herbal Remedies

  112. 5/10/02 Herbal Medicine: Expanded Commission E Monographs

  113. 5/10/02 Pdr for Herbal Medicines (Physician's Desk Reference for Herbal Medicines, 2nd Ed)

  114. 5/10/02 The American Pharmaceutical Association Practical Guide to Natural Medicines

  115. 5/10/02 Living Proof: A Medical Mutiny Michael Gearin-Tosh - Review 1 - Review 2

  116. 7/26/02 Choices in Healing Michael Lerner - FULL TEXT free online!

    Herbal Reference

  117. 5/3/02 How Do Herbal Resources Measure Up? Seena Zierler-Brown and J. Bryan Walker Journal of the American Pharmaceutical Assn. List of Herbal Reference and Websites

  118. 9/10/01 HerbMed Database of herbs, interactions, uses, etc.

  119. 10/27/01 People's Pharmacy Herb Library

  120. 1/7/02 Healthwell Herb Encyclopedia

  121. 1/19/02 Alternative Medicine Guides Herb Guide - SAME AS HEALTHWELL

  122. 10/24/02 Intelihealth Herb Library

  123. 1/21/02 The Natural Pharmacist Herb Encyclopedia

  124. 7/25/01 WholeHealthMD.com Herbals, News, Encyclopedia, etc

  125. 4/21/02 Dr. Duke's Phytochemical and Ethnobotanical Databases Enter an herb, find out chemical composition, OR enter a compound, find herbs having that compound in high concentration.

  126. 4/21/02 Update on Natural Product-Drug Interactions from American Journal of Health-System Pharmacy Gayle Nicholas Scott, Pharm.D., FASCP, BCPS, CGP and Gary W. Elmer, PH.D. The interactions of natural products with drugs are discussed. Interactions between natural products and drugs are based on the same pharmacokinetic and pharmacodynamic principles as drug-drug interactions. Clinically important interactions appear to involve effects on drug metabolism via cytochrome P-450 isoenzymes, impairment of hepatic or renal function, and other possible mechanisms.

  127. 4/21/02 CAM Databases from NCCAM

  128. 4/21/02 Dietary Supplements Resource List Food and Nutrition Information Center National Agricultural Library/USDA February 2002 This resource list contains sources of general information on the uses and risks of dietary supplements. The resources selected include nutrition information on phytochemicals, vitamins, minerals, herbs, botanicals, and other plant-derived substances; melatonin; amino acids, fatty acids, concentrates, metabolites, and constituents and extracts of these substances

  129. 8/3/02 A Consumer's Guide to Herbal Medicines

  130. 9/16/02 Herbs and Supplements

    Sources of Herbs

  131. 1/7/02 Iherb.com Online Store

  132. 1/30/02 Life Extension Foundation

    Bulletin Board Posts

  133. 1/20/02 Beyond Aspirin - Intro

  134. 1/20/02 Beyond Aspirin II

  135. 1/30/02 Beyond Aspirin III - Trans Fatty Acids and Colon Cancer

  136. 1/20/02 Resveritrol

  137. 1/20/02 Bromelain

  138. 1/20/02 PSK

  139. 1/20/02 Oltipraz - Summary

  140. 1/20/02 Milk Thistle

  141. 1/20/02 A Consumer's Guide to Herbal Medicines

  142. 1/20/02 Understanding the Perceived Need for Complementary and Alternative Nutraceuticals: Lifestyle Issues Clinical Journal of Oncology Nursing Article

  143. 1/30/02 Food is Medicine in Colon Cancer Fight - Article

  144. 1/30/02 Bee Products - Honey, Propolis

    Cancer Chemoprevention

  145. 6/5/02 Chemoprevention of Cancer Scientific American

  146. 7/19/01 Regulation of Tumor Angiogenesis by Dietary Fatty Acids and Eicosanoids David P. Rose and Jeanne M. Connolly [Nutrition and Cancer 37(2):119-127, 2000. - FULL TEXT PAPER - Angiogenesis is a prerequisite for tumor growth and metastasis. Vascular endothelial cell proliferation, migration, and capillary formation are stimulated by angiogenic growth factors, which include the proteins vascular endothelial growth factor, basic fibroblast growth factor, and transforming growth factor- , and eicosanoids synthesized from n-6 fatty acids. Clinical studies have shown that angiogenesis in solid tumors relates to a poor prognosis and, in premalignant lesions, indicates potential for cancerous transformation. High-fat, n-6 fatty acid-rich diets were associated with a relatively poor prognosis in breast cancer patients; in a nude mouse model the same diet enhanced breast cancer progression, whereas n-3 fatty acids exerted suppressive effects that were associated with impaired angiogenesis. Lipoxygenase and cyclooxygenase products of n-6 fatty acid metabolism are angiogenic in in vitro assays. This activity is blocked by pharmacological inhibitors of eicosanoid biosynthesis, and one, indomethacin, suppressed n-6 fatty acid-stimulated murine mammary carcinoma growth and metastasis and tumor vascularization. Review of the experimental data suggests that selective inhibitors of eicosanoid-synthesizing enzymes and dietary intervention with n-3 fatty acids merit clinical evaluation as adjuvant therapy and chemopreventive agents

  147. 6/6/02 COX-2 Inhibitors for Cancer Prevention and Therapy ASCO 2002 Hear Actual Lectures and View Slides from the ASCO meeting

  148. 6/5/02 New Cancer Prevention Investigations Focus on Food, Lifestyle Factors ASCO 2002 Dr. Greenwald outlined a specific metabolic pathway that is closely tied to the process of cancer development. "The arachidonic acid metabolic pathway is the target for several chemopreventive agents and is also influenced by what you choose to eat," he said. "One leg of this pathway is controlled by cyclooxygenases (COX) and affects the synthesis of prostaglandins and thromboxanes; this is why people take aspirin to prevent heart attacks. The other is controlled by lipoxygenases (LOX), which affect leukotrienes-mediators of inflammation and ligands to peroxisome proliferator-activated receptors (PPARs)-which are products of the LOX pathway and may impact carcinogenesis." Linoleic acids, or essential fatty acids (vegetable oils), are the food source for arachidonic acid. COX inhibition is important, because COX-2 is expressed in all stages of human colon neoplasia. "The use of nonsteroidal anti-inflammatories has been used to protect against polyps and to lower colon cancer incidence and mortality," said Dr. Greenwald. "This is a great synthesis of epidemiology and the biology of cancer prevention research." Clinical studies are currently underway to further study and quantify this effect. Inhibiting LOX may be useful in preventing lung and other cancers. "We think LOX inhibitors, or leukotriene modulators, used for asthma should be tested for chemopreventive activity, especially with former smokers. LOX inhibitors reduce inflammation in the lung, white cell migration, and bronchospasm. Since the inflammatory process in some instances may predispose to cancer, we think this needs further study," said Dr. Greenwald. "We also know that LOX mRNA is present in lung cancer cell lines, that a LOX inhibitor slows adenocarcinoma cell growth, and that it slows lung tumor xenograph growth in mice. LOX inhibitors also slow the growth of breast and colon cancer cell lines."

  149. 6/5/02 Celecoxib attenuated capecitabine induced hand-and-foot syndrome (HFS) and diarrhea and improved time to tumor progression in metastatic colorectal cancer (MCRC) -ASCO 2002 Abstract- We undertook a retrospective analysis of 67 mCRC patients (pts) taking either capecitabine and celecoxib (A) or capecitabine alone (B) in first/second line settings. The doses of capecitabine were comparable for A & B and 31/32 pts in A received Celecoxib 200 mg BID for pain indications. Patient characteristics favored B: median age (55 vs 65), better PS, and chemo-naïve. (31% vs 11%) 50% of the patients in A/B had failed CPT11 and/or Oxaliplatin. Rates of SD (62.5% vs 22.8%) and CEA decline (75% vs 22.8%) occurred in A & B respectively. 2/7 PRs in pts with prior irinotecan occurred only in A. Median time to tumor progression (mTTP) in A & B was 6 vs 3 months respectively and TTP of 10+ months was not reached for 6 Pts in A. HFS, diarrhea and pain were noticeably reduced in A. Interestingly, three pts experienced worsening HFS and diarrhea upon discontinuation of celecoxib. Survival data will be presented. A prospective trial is planned

  150. 6/5/02 A suppression efficacy against the hematogenous metastases of adjuvant immunochemotherapy with protein bound polysaccharide K (PSK). -ASCO 2002 Abstract- (NOTE: PSK is an AVAILIABLE Mushroom Extract) At four weeks after surgery, Group P began to receive alternately oral PSK (3g/day) for four weeks and oral 5-FU (200mg/body/day) for four weeks as one course: Ten courses were given. Group C received 5-FU alone for four weeks in an alternate rest interval for the same period. The seven-year disease-free survival (DFS) and overall survival (OS) were 80.5% and 85.4% in Group P, and 60.5% and 65.1% in Group C, respectively. There were significant differences between these two groups on both DSF and OS. Then, we also evaluated the efficacy on a suppression of metastases by PSK. Subgroup analysis of logarithmic hazard rates revealed that PSK was markedly proved to be more effective on hematogenous metastases rather than on other metastases.

  151. 6/5/02 Cimetidine increases survival of colorectal cancer patients with high levels of sialyl Lewis-X and sialyl Lewis-A epitope expression on tumour cells - FULL TEXT - British Journal of Cancer, 21 January 2002, Volume 86, Number 2, Pages 161-167 Pubmed Abstract PMID: 11870500 Robust beneficial effects of cimetidine were noted: the 10-year survival rate of the cimetidine group was 84.6% whereas that of control group was 49.8% (P<0.0001). According to our previous observations that cimetidine blocked the expression of E-selectin on vascular endothelium and inhibited the adhesion of cancer cells to the endothelium, we have further stratified the patients according to the expression levels of sialyl Lewis antigens X (sL(x)) and A (sL(a)). We found that cimetidine treatment was particularly effective in patients whose tumour had higher sL(x) and sL(a) antigen levels

  152. 04/21/2001 Cancer Fighters in Your Spice Rack Summary of Natural COX-2 Inhibitors: Turmeric (curcumin), Red grapes, Rosemary, Green Tea, Bee Propolis

  153. 1/30/02 A review of cancer chemopreventive agents Curr Med Chem 2001 Sep;8(11):1349-62 PMID: 11562271 Retinoids, vitamin A derivatives, such as targretin and fenretinide are useful in the prevention of tumors. Compounds containing sulfur, such as sulforaphane and oltipraz, are even useful as radioprotective agents. The steroid dehydroepiandosterone can inhibit experimental carcinogenesis. All of these chemical classes provide a start for the medicinal chemist to design more effective chemopreventive agents

  154. 1/30/02 Molecular mechanisms underlying chemopreventive activities of anti-inflammatory phytochemicals: down-regulation of COX-2 and iNOS through suppression of NF-kappa B activation. Mutat Res 2001 Sep 1;480-481:243-68 PMID: 11506818 A wide array of phenolic substances, particularly those present in edible and medicinal plants, have been reported to possess substantial anticarcinogenic and antimutagenic activities. The majority of naturally occurring phenolics retain antioxidative and anti-inflammatory properties which appear to contribute to their chemopreventive or chemoprotective activity. Cyclooxygenase-2 (COX-2) inducible and nitric oxide synthase (iNOS) are important enzymes that mediate inflammatory processes. Improper up-regulation of COX-2 and/or iNOS has been associated with pathophysiology of certain types of human cancers as well as inflammatory disorders. Since inflammation is closely linked to tumor promotion, substances with potent anti-inflammatory activities are anticipated to exert chemopreventive effects on carcinogenesis, particularly in the promotion stage. Examples are curcumin, a yellow pigment of turmeric (Curcuma longa L., Zingiberaceae), the green tea polyphenol epigallocatechin gallate (EGCG), and resveratrol from grapes (Vitis vinifera, Vitaceae) that strongly suppress tumor promotion

  155. 1/30/02 The role of cyclooxygenase and lipoxygenase in cancer chemoprevention. Drug Metabol Drug Interact 2000;17(1-4):109-57 PMID: 11201293 The involvement of prostaglandins (PGs) and other eicosanoids in the development of human cancer has been known for over two decades. Importantly, an increase in PG synthesis may influence tumor growth in human beings and experimental animals, and numerous studies have illustrated the effect of PG synthesis on carcinogen metabolism, tumor cell proliferation and metastatic potential. PGs produced by cyclooxygenases (COXs) are represented by a large series of compounds that mainly enhance cancer development and progression, acting as carcinogens or tumor promoters, with profound effects on carcinogenesis. Further investigations suggest that arachidonic acid (AA) metabolites derived from lipoxygenase (LOX) pathways play an important role in growth-related signal transduction, implying that intervention through these pathways should be useful for arresting cancer progression. We discuss here the implications of COX and LOX in colon, pancreatic, breast, prostate, lung, skin, urinary bladder and liver cancers. Select inhibitors of COX and LOX are described, including nonsteroidal antiinflammatory drugs (NSAIDs), selective COX-2 inhibitors, curcumin, tea, silymarin and resveratrol, as well as a method useful for evaluating inhibitors of COX

  156. 1/30/02 Chemoprevention of colorectal cancer. Am J Gastroenterol 2002 Jan;97(1):13-21 PMID: 11808936 Epidemiological studies have consistently shown that chronic intake of nonsteroidal anti-inflammatory drugs (NSAIDs), principally aspirin, can reduce the incidence of colorectal adenomas and carcinomas. Evaluation of NSAIDs, including newer selective cyclo-oxygenase-2 inhibitors, in carcinogen-induced and genetically manipulated animal models of colorectal cancer demonstrates that these drugs are effective chemopreventive agents More recently, the selective cyclo-oxygenase-2 inhibitor Celebrex was also shown to be effective in familial adenomatous polyposis and was approved by the Food and Drug Administration as a adjuct to usual care in these patients. NSAIDs, as well as other chemopreventive agents, are currently being studied in patients at increased risk of colorectal cancer, including those with sporadic adenomas Chemopreventive strategies, if effective, offer the promise of producing a paradigm shift in our current approach to colorectal cancer.

  157. 2/3/02 COX-2 Inhibitors - Present Realities, Future Possibilities June 2000 Certified for 1 hour of Category 1 AMA Credit Sponsored by the University of Alabama School of Medicine Division of Continuing Medical Education

  158. 6/5/02 DIETARY FLAVONOIDS: Bioavailability, Metabolic Effects, and Safety. Annu Rev Nutr 2002;22:19-34 PMID: 12055336 The six major subclasses of flavonoids include the flavones (e.g., apigenin, luteolin), flavonols (e.g., quercetin, myricetin), flavanones (e.g., naringenin, hesperidin), catechins or flavanols (e.g., epicatechin, gallocatechin), anthocyanidins (e.g., cyanidin, pelargonidin), and isoflavones (e.g., genistein, daidzein).

  159. 9/16/02 Cancer preventive effects of flavonoids--a review. Biomed Pharmacother 2002 Aug;56(6):296-301 PMID: 12224601 A cancer protective effect from plant-derived foods has been found with uncommon consistency in epidemiologic studies. However, it has been difficult to identify specific components responsible for this effect. Many phytochemicals have been shown to be biologically active and they may interact to protect against cancer. In recent years, experimental studies have provided growing evidence for the beneficial action of flavonoids on multiple cancer-related biological pathways (carcinogen bioactivation, cell-signaling, cell cycle regulation, angiogenesis, oxidative stress, inflammation). Although the epidemiologic data on flavonoids and cancer are still limited and conflicting, some protective associations have been suggested for flavonoid-rich foods (soy and premenopausal breast cancer; green tea and stomach cancer; onion and lung cancer). This review focuses on the biological effects of the main flavonoids, as well as the epidemiologic evidence that support their potential cancer protective properties

  160. 6/5/02 Inhibitory effect of mandarin juice rich in beta-cryptoxanthin and hesperidin on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced pulmonary tumorigenesis in mice. Cancer Lett 2001 Dec 28;174(2):141-50 PMID: 11689289 principle chemopreventive factors in MJs may be beta-cryptoxanthin and hesperidin. Present study was conducted to test whether these MJs could modify carcinogenesis in other organ, lung These findings might suggest that MJ5, which contain 3.9 mg beta-cryptoxanthin and 100 mg hesperidin in 100 g sample), has chemopreventive ability against NNK-induced mouse lung tumorigenesis

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    Arthritis/Ulcerative Colitis

    Because of the apparent connections between "Inflammatory Conditions" such as arthritis and/or ulcerative colitis and cancer (See e.g. the "Beyond Aspirin" posts here ), herbs/supplements which benefit arthritis may also benefit cancer patients. Arthritis is EASIER for researchers to study with regard to supplements, so there may be a little more information available about herbal arthritis remedies. Whether any of these efficacy results would somehow carry over into cancer chemoprevention is of course unknown, but my guess is in the future many of the "new results" regarding herbal cancer therapy/chemoprevention will involve use of these herbs.

  161. 1/30/02 Chronic Inflammation - LEF Article

  162. 3/21/02 Herbs for Gout Flavonoids, which are water-soluble plant pigments, are part of a large group of antioxidant phytochemicals. Chamomile (Matricaria recutita), chiso (Perilla frutescens), many mints (Mentha spp.) and yarrow (Achillea millefolium) are rich in luteolin, apigenin and caffeic acids Baikal skullcap (Scutellaria baicalensis) and Taiwanese skullcap (S. rivularis) contain baicalein as well as several other anti-inflammatory flavonoids. Both the isolated flavonoids and herbal extracts from skullcap have shown effectiveness against paw inflammation in mice and are used traditionally for chronic inflammatory conditions and liver disorders.8,9 I recommend a combination of the herbs daily as a preventive measure: three capsules each of standard dose baikal skullcap, chamomile and yarrow. Incorporating chiso leaf and peppermint tea is also a good idea. Keep in mind that quite high doses of these herbs are needed to make an impact, but they can be supportive when taken in conjunction with diet modification

  163. 1/30/02 Rheumatoid Arthritis

  164. 1/30/02 Safe Herbal Anti-Inflammatories June 1, 2001, 9:57 a.m. EDT HERBS VS. DRUGS: WHAT'S THE DIFFERENCE? Herbs work completely differently than drugs. Drugs isolate a single "active" ingredient with a single targeted effect. They can be effective in treating the targeted area of the body, but they can trigger a host of unhealthy, serious negative side effects and overall be very unbalancing to the body. On the other hand, herbs use the intelligence of the whole plant or parts of the whole plant. Instead of one active ingredient, there are thousands of natural compounds that all work together in an organized fashion to not only treat the fundemental imbalance, but to balance and support the whole body enlivening the physiology's healing intelligence. Generally when taken properly, herbs have few if any side effects and usually have many side benefits. TAKE 2 HERBS AND CALL ME IN THE MORNING There are many well-researched herbs with anti-inflammatory effects just as effective as aspirin and non-steroidal anti-inflammatories. But unlike these drugs -- which can cause stomach problems like potentially fatal bleeding ulcers --these herbs have properties that actually help protect the stomach from ulcers. Green tea, holy basil, turmeric and ginger are a few of the herbs with these beneficial effects. HERBAL ASPIRIN SUBSTITUTE AND OTHER BENEFITS Research has found that herbs like ginger, green tea, barberry, holy basil, turmeric, rosemary and oregano (the pizza spice) have many other benefits beyond reducing pain and inflammation. Most of these herbs promote wound healing, inhibit cancer and help prevent Alzheimer's. Ginger, for example, has more than 477 different constituents identified so far that have anti-inflammatory, anti-ulcer, anti-oxidant, anti-tumor and anti-nausea effects. It also lowers cholesterol and promotes good digestion, containing 180 times more protein-digesting enzymes than papaya.

  165. 1/30/02 Ulcerative Colitis - Healthwell Notes

  166. 1/30/02 Digestive Enzymes Also indexed as: Pancreatic Enzymes, Pancreatin, Papain, Proteolytic Enzymes Proteolytic enzymes such as trypsin, chymotrypsin, and bromelain are partially absorbed by the body.4 5 6 Once absorbed, they have anti-inflammatory activity and may even demonstrate antitumor effects.7 8 9 10 Proteolytic enzymes may also improve immune system function, for example, in people with shingles (herpes zoster), though this area of research has been poorly explored

  167. 1/30/02 Crohn's Disease - Healthwell Notes Herbs that may be helpful: Doctors sometimes use a combination of herbs to soothe inflammation throughout the digestive tract. The formula contains marshmallow, slippery elm, cranesbill, and several other herbs. Marshmallow and slippery elm are mucilaginous plants that help soothe inflamed tissues. Cranesbill is an astringent. Clinical trials using this combination have not been conducted. A variety of anti-inflammatory herbs have historically been recommended by doctors for people with Crohn's disease. These include yarrow, chamomile, licorice, and aloe juice. Cathartic preparations of aloe should be avoided. No research has been conducted to validate the use of these herbs for Crohn's disease.

  168. 3/24/02 Arthritis and Inflammation Neutratherapeutics

  169. 3/24/02 LEF Arthritis Protocol

  170. 3/24/02 Chronic Venous Insufficiency Healthwell Notes. These herbs MAY be able to inhibit metastasis by reducing vascular permeability.

  171. 5/5/02 Arthritis - Holistic Online

  172. 5/5/02 Rheumatoid Arthritis - Holistic Online

  173. 4/20/02 Herbal Anti Inflammatories G. Douglas Andersen,DC,DACBSP,CCN Description of general classes of herbs

  174. 4/20/02 Natural COX-2 Inhibitors

  175. 5/5/02 Cancer - Holistic Online

    Miscellaneous

  176. 6/2/02 Doctoryourself.com

  177. 6/2/02 Chemotherapy - Do We Need a New Approach to Cancer?

  178. 6/2/02 The Doctor Within - To the Cancer Patient

  179. 6/2/02 Dr. Gonzalez Treatment Regimine

  180. 6/2/02 Alternative Cancer Treatments

  181. 6/2/02 The MD as alternative practitioner

  182. 6/5/02 BB Post - Hulda Clark and Cancell

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