This webpage is about methods and tools for structural and functional research in biomedicine, drug discovery and development. It deals with methods to explore the complex relation between biological function and structure at multiple levels of biological systems.
We are currently in a transition stage from genomics to proteomics towards system level cytomics. With the increasing availability of tools and instruments, such as High Content Screening, and molecular medicine, etc. to study penomena of increasing spatial, spectral and temporal dimensionality and complexity at high speed and quality, quantifying and analysing biological phenomena of a higher order of complexity will be possible at high speed. The tools to extract high order feature spaces and extract knowledge and understanding from biological levels of complexity previously out of reach bring us closer to capturing and understanding the intrahuman ecosystem.
A human cytome project aims at creating a better understanding of a cellular level of biological complexity in order to allow us to close the gap between (our) molecules and the intrahuman ecosystem. Understanding the (heterogeneous) cellular level of biological organisation and complexity is (almost) within reach of present day science, which makes such a project ambitious but achievable. A human cytome project is about creating a solid translational science, not from bench to bedside, but from molecule to man.
Scale space and the spatial color model are powerful techniques for quantitative digital microscopy and high content screening.
Application of linear scale space and the spatial color model in light microscopy.
Automated Tiled Multi-mode Image Acquisition and Processing Applied to Pharmaceutical Research.
The M5 framework for exploring the cytome.
I am indebted, for their pioneering work on automated digital microscopy and High Content Screening (HCS) (1988-2001), to my former colleaguas at Janssen Pharmaceutica (1997-2001), such as Frans Cornelissen, Hugo Geerts, Jan-Mark Geusebroek, Roger Nuyens, Rony Nuydens, Luk Ver Donck and their colleaguas. Many thanks also to the pioneers of Nanovid microscopy at Janssen Pharmaceutica, Marc De Brabander, Jan De Mey, Hugo Geerts, Marc Moeremans, Rony Nuydens and their colleagues. I also want to thank all those scientists who have helped me with general information and articles.
A Human Cytome Project - discussion
Drug Discovery and Development - Human Cytome Project
Human Cytome Project - How to Explore
A framework for cytome exploration
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Created by Peter Van Osta, MD, see also Software Engineering for Science.
Private email: pvosta at cs dot com