Resume

Personal information

Peter Van Osta Peter Van Osta, MD
Born in Belgium, Europe on 17 May 1965.
Living in Belgium, Europe.
Private email: pvosta {at} cs {dot} com
Mobile: +32 (0)497 228 725
Fax: +32 (0)3 385 39 21
LinkedIn: Peter Van Osta
Skype: pvosta2390

Summary

An MD and biochemist with a keen interest in process and technology innovation in the pharmaceutical industry and in healthcare (eHealth). My main interest is about improving the link between business, science and technology.

Process and technology innovation in Life Sciences and healthcare (eHealth). Process improvement (CMMI) and Quality Assurance (QA). More than eight years of experience in technology development in High Content Screening (HCS) and digital image analysis.

Keywords

Index

Employment history

Current employment

"A ICT Company"
Service Division
Belgium

Since 7 November 2005, I am working for an ICT company, first as Senior Consultant and since June 2006 also as Quality Officer. Our company recently became CMMI ML2 certified, for which I established the Quality Office.
In Life Science, me and my team work on the innovation, design, development and implementation of (new) business processes and IT-systems in order to improve the efficiency and efficacy in healthcare (eHealth) and in the Life Science industry.
Under my guidance, a corporate helpdesk was implemented in order to improve our services towards our customers. I created a QA Office for this company and as a Quality Officer I work on internal process improvement (CMMI ML2-3, ...) and implement new processes in our organization in order to improve the performance and quality of our projects and the service towards our customers. I audit and coach our software development projects to improve our performance and increase customer satisfaction. Therefore I also train my colleagues on process management principles and project management according to CMMI and best practices we implemented in our company.

The BioPharmaTechnology House

The BioPharmaTechnology House
De Biezen 22
B-2450 Meerhout
Belgium

From 16 July 2005 until 1 September 2005 I was working as Senior Consultant for The BioPharmaTechnology House (BPTH) which develops technology for the pharmaceutical and biotech industry. The company is specialised in supporting pharmaceutical laboratories including measuring setups as well as laboratory information management systems (LIMS).

MAIA SCIENTIFIC

MAIA SCIENTIFIC NV - formerly known as Union Biometrica ESO
A Harvard Bioscience Company
Cipalstraat 3
B-2440 Geel
Belgium

From 2 July 2001 until 20 May 2005 (15 July 2005), I was working for MAIA SCIENTIFIC as Director Imaging Technology and IT. We developed High Content Screening (HCS) systems and advanced multi-mode image processing software based on scale space and the spatial color model. The system was used for automated multi-mode cell based research and tissue morphology (histology) and could be integrated into large scale automated screening systems. I managed the software development team and the software development projects and designed the software for the MIAS 2 and the Cello Companion.
I was responsible for managing the design and development of a high-end system for High Content Screening (HCS) for which I used an agile software engineering process. We used both procedural as well as Object-Oriented programming techniques for software engineering. My team was also responsible for automated system integration testing of both software and hardware. We managed the IT infrastructure of the company (Linux-server, Linux and MS-Windows clients).

We designed the software components so they would allow to allow for scaleable, distributed, high-volume screening and analysis (HCS, HCA) and to facilitate embedding the system in a multi-platform automated workspace. The use of open standards (C, C++, CORBA, .NET, XML, ASCII, etc.) in a (Unix) Linux environment allowed for cross-platform integration and data transfer. The system was based on a Carl Zeiss Axiovert 200M inverted microscope, combined with hardware add-ons for further automation (robotics, barcode reader).

We used linear isotropic scale-space and the spatial colour model for advanced object detection. For each detected object (cell, organelle, tissue segment …) the system created a high-dimensional and linked feature hyperspace for in-depth analysis and exploration of cellular structure and function (High Content Analysis, HCA). The application development framework allowed for rapid development of multi-mode imaging applications for both brightfield as well as fluorescence imaging applications over a wide range of resolutions and magnifications.

Based on my own experience in the pharmaceutical industry and biotech and the state of research technology, I made a suggestion on Monday, 1 December 2003 about the concept of a Human Cytome Project (HCP) to improve the efficiency and effectiveness of the drug discovery and development process.

Janssen Pharmaceutica


Janssen Pharmaceutica NV (a Johnson & Johnson company)
Turnhoutseweg 30
B-2340 Beerse
Belgium

From 31 Dec. 1996 until 30 June 2001, I worked as Senior Scientist Biomedical Imaging at the Biological Imaging Laboratory team of the Life Science Department (project management, software development).

Our team worked on imaging projects for drug discovery and preclinical development. I contributed to several research programs in CNS, oncology, cardiology and other disease areas. My main responsibility within the team was to support research projects which required automated quantification of image data: (tissue) morphology, brightfield screening, High Content Screening (HCS), C. elegans projects and MRI for small lab animals. Our imaging team developed fully automated solutions for both brightfield as well as fluorescence imaging. Part of this also involved time-lapse and real-time microscopy for dynamic in-vivo studies (e.g. Ca2+ ratio imaging). Our work was done in close collaboration with several research groups from different departments in the company. We used both Unix as well as MS-Windows based software for developing applications for automated digital microscopy (mainly on Unix and in ANSI C). For this purpose we mainly used computer controlled (Silicon Graphics, MS-Windows) microscopes (ZEISS, Leica) equipped with several types of CCD-cameras and motorized stages. I co-developed and improved the ( Unix and MS-Windows) software for image acquisition and -analysis (MultiMode tiled Mosaic microscopy framework, M3). The Unix system was capable of tiled multi-mode microscopy of several tissue slides or multiwell plates either with colour cameras or intensified cameras.
A framework existed for simultaneous automatic acquisition and analysis of multiple time-lapse movies at multiple positions and intervals, with intervals ranging from real-time up to several hours per movie frame. We used linear isotropic scale-space and the spatial colour model for advanced object detection.
An article on our work and about modern high-end automated image acquisition and analysis in drug discovery and development is available:
Image Analysis gives a clear view in research. I was also involved in an initiative to start with MRI imaging of transgenic disease models.

I proposed and managed the development of a large-scale high-throughput multimedia database for discovery research. I designed and developed an Intranet site to improve the quality of structural research by providing extensive information about digital microscopy, image analysis and research methodology. Part of the first website for the research department at this company was a copy of my own first academic website of 1995. In 1997 I proposed and introduced SAMBA as a way to exchange data between Unix systems and MS-Windows. In 1998 I proposed and introduced Linux as a research platform for image analysis.

During this period I also started a small company, together with a friend, specialised in Linux networking. Although it is not a big company it has been fun to do and I have certainly learned a lot about running a small business and setting up a Linux based network infrastructure.

University of Antwerp

University of Antwerp (UIA)
Universiteitsplein 1
B-2610 Wilrijk,Antwerpen
Belgium

From 1 Jan. 1996 until 31 December 1996 I worked at the Department of Biochemistry as a researcher on protein pattern analysis and bioinformatics. I worked for the Laboratory of Protein Chemistry (Prof. L. Moens, Ph.D.) and Molecular Genetics (Prof. C. Van Broeckhoven, Ph.D.). My main task was the follow-up and analysis of 2D PAGE for a project on Alzheimer Dementia (AD). For the analysis of the 2D PAGE I mainly used the BioImage software package on a Sun SPARCstation.
At the Laboratory for Molecular Genetics I was also responsible for bioinformatics. I set up a Linux server for web-, print- and file serving (Mac and PC clients) and for bio-informatics applications. I learned a lot about using Unix (Linux) systems for biomedical research.

University of Gent

University Hospital - UZ Gent
De Pintelaan 185
B-9000 Gent
Belgium

From 1 April 1995 until 31 Dec. 1995 I did research at the Department of Medical Genetics of the University of Gent (RUG), Belgium (Prof. A. De Paepe, MD, Ph.D.). My main job was the follow-up and screening of mutations in the FBN1 gene of patients with Marfan Syndrome.
I started the first website of the Department of Medical Genetics in August 1995.

Lasion Europe NV

Lasion Europe NV
Kontichsesteenweg 40
B-2630 Artselaar
Belgium

From 4 Oct. 1993 until 15 March 1995 I worked at Lasion Europe NV, (CEO T. Aernouts, MD) as a Project Manager (PM) for medical multimedia publications on CD-ROM (Production Manager Chris de Laet, MD). In order to improve the data- and workflow I developed an automatic multimedia document management system for the (pre-) processing of images and texts.

This job taught me a lot about efficient production planning and organisation. Besides this I learned to appreciate working with a team of highly qualified professionals on high-tech projects.

University of Antwerp

University of Antwerp (UIA)
Universiteitsplein 1
B-2610 Wilrijk, Antwerpen
Belgium

From 3 Aug. 1992 until 1 Oct. 1993 I worked (community service) at the Department of Medical Genetics of the University of Antwerp (Prof. J. Dumon, MD, Ph.D.). I did counselling for prenatal diagnosis and congenital disorders and research on the prenatal diagnosis for Spinal Muscular Dystrophy type I (SMA I). Besides this I started research on oncogenes in the disease process of Astrocytoma.
On my own initiative I started the international data communication on the Internet for the Department. I also improved the scientific computing and the computer support for the Department.

Student jobs

- Clerk at the Social fund of the V.E.V., Antwerp , 1/8/1983 - 31/8/1983.
- Designing and programming a self-evaluation program at the L.U.C., Diepenbeek , Belgium , 4/8/1986 - 5/9/1986 (my own idea). They developed it afterwards to a full multimedia application.
- Participating in a clinical trial at the Department Nephrology U.Z.A., 1/7/1988 - 31/7/1988.
- Bacteriological drinking water analysis in the bacteriological laboratory of the A.W.W., Antwerp, Belgium, 15/7/1988 - 12/8/1988
- Processing of bloodsamples in the Red cross bloodtransfusion center, Antwerp, Belgium, 1/2/1988 - 31/5/1988
- Clerk (sales) at IKEA Wilrijk, Belgium, 8/4/1991 - 13/4/1991
- Medical support (night) at Eurocall International Assistance, Zwijndrecht, Belgium, 1/7/1991 - 31/7/1991

Education

Primary school (1st to 6th grade)

Broederschool Sint-Jozef, Kapellen, Belgium.

From 1971 until 1977.

Secondary school (7th to 12th grade)

Moderne Humaniora (A.S.O.), Wetenschappen B
Sint-Lambertusinstituut, Ekeren, Belgium.

From 1977 until 1983.

Higher education (University)

Medicine (first cycle)

Limburgs Universitair Centrum (LUC), Diepenbeek, Belgium.
15 September 1984 - 15 July 1987

Medicine (second cycle, MD)

Doctor in de Genees-, Heel- en Verloskunde
Universitaire Instelling Antwerpen (UIA), Antwerp, Belgium.
1 October 1987 - 28 June 1991.

Postgraduate education (University)

G.A.S. Biochemistry

G.A.S. Biochemie
Universitaire Instelling Antwerpen (UIA), Antwerp, Belgium.
15 September 1992 - 6 July 1993.

Thesis

Medicine: Detection of Medium Chain Acyl-CoA Dehydrogenase as a cause of S.I.D.S..
Promoter: Prof. J. Dumon, MD, Ph.D., Dept. Medical Genetics, UIA

Biochemistry: Research at the possibility of prenatal diagnosis of Spinal Muscular Atrophy type I by means of DNA research.
Promoter: Prof. P. Willems, MD, Ph.D., Dept. Medical Genetics, UIA

Additional education

Management

- Project Management, Janssen Pharmaceutica, Sept. 1998.
- Introduction Network Management , CMO Turnhout, Belgium, 1999.
- Management for small and medium-sized enterprizes, CMO, Turnhout, Belgium, Sept. 2001 – June 2003.
- Accountability training, The Oz Principle, Kontich, Belgium, 27 Jan. 2006.
- Project Management Body Of Knowledge (PMBOK) (self-education)
- Software Engineering Body Of Knowledge (SWEBOK) (self-education)
- Capability Maturity Model (CMMI) (PP, PMC, SAM, REQM, MA, PPQA, CM, in-company training)

Technical / Scientific

- Working with dBase IV, C.B.L. UIA, April 1993
- Thirteenth Special Course on Image Processing for Industrial Applications, T. U. Delft, the Netherlands, 13 - 17 January 1997
- Mathematical Morphology: Principles, Algorithms and Applications. ASCI Course a11, University of Amsterdam, 23 - 27 June 1997.
- Introduction to Biostatistics, Janssen Research Foundation, 1997.
- Summer School in Light Microscopy, Royal Microscopical Society, University of Leeds, Leeds, UK, July 1998.
- C++ course, VDAB, Edegem, Belgium , Dec. 1998 - Jan. 1999.
- Crash course S-Plus, Janssen Pharmaceutica, Beerse, Belgium, 5 May 2000
- Front-end Vision and Multiscale Image Analysis 1999, an introduction to Scale-Space Theory. Utrecht University Hospital, Utrecht, the Netherlands., October 1999.
- In vivo MRI, University of Wageningen, the Netherlands, 16-27 October 2000.

Professional experience

People and Project Management

Functional management of a software development team
Project management (initation, execution, closure)
Process management (incl. Quality Assurance, PPQA)

Biomedical Science and Technology

Automated Digital Microscopy

Technology development for drug discovery and preclinical development.
High Content Screening (HCS) and High Content Analysis (HCA)
Bright field microscopy, fluorescence, phase contrast and DIC.
Digital multi-mode microscopy
Video microscopy (time-lapse, real-time)
Multidimensional microscopy: spatial, spectral and temporal.

Magnetic Resonance Imaging (MRI)

Basic knowledge of the principles of in-vivo imaging and MRI

Information Technology (IT)

Software Engineering

Plan-driven (WF, Iterative) and Agile Lifecycle
Functional analysis and design
Procedural and OO software development
Programming languages: ANSI C, C++
Version control: CVS, Subversion
Bug and feature tracking: Bugzilla, Mantis
Debugging: DDD, GDB
Advanced image processing: scale space, spatial color model, video
Microscopy reader automation and remote control: Carl Zeiss Axiovert 200M, MIAS-1 and MIAS-2
Image processing software development: Eazyx 2.x (M5 kernel), SCIL Image 1.4 (Unix), Optimas
Graphical User Interface (GUI) development: GNOME, GTK+
Distributed cross-platform computing: CORBA
Datacommunication: TCP/IP (sockets), serial (RS-232)
Microscopy driver development (SGI, Linux): Carl Zeiss Axiovert 100M and 200M.
Driver for motorized microscope XY stage (SGI, Linux): ITK controller with Maerzhauser stage (MAC 4000 and VENUS 2 protocol)
Video, data capture: framegrabber software library (SGI, MPEG-1, QuickTime on Linux), video processing

Software

Office software: MS-Office Professional (MS-Word, Excel, Access, PowerPoint), OpenOffice
Internet-tools: IE, Mozilla, HTML-editing, FTP
Databases: PostgreSQL, MySQL
Mathematics: Mathematica
CD-ROM Publishing: Publishing Software Lasion, version 1.7.4 (1994)
Text processing: MS-Word Macro based text processing system (1993-1994)
Regulations: FDA CFR Title 21 Part 11 (electronic records and electronic signatures), GLP

Hardware

PC
Silicon Graphics Indy and O2 (SGI)
Apple
Palm PDA

Operating Systems

Unix: RedHat Linux, Fedora Linux and SGI Irix (5.x, 6.x)
MS-DOS (5 and 6), MS-Windows 3.1 to XP

Clinical experience

Medical genetics, University Hospital Antwerp (UZA)
Prenatal counselling (1992 - 1993)

Laboratory experience

Automated digital microscopy - High Content Screening (1997-2005)

Experiment design and development.
Digital microscopy assays for drug discovery and preclinical development.
Assay automation (cell-based assays, histology, model organisms).
Brightfield and fluorescence microscopy.
Video and time-lapse microscopy.

Molecular biological techniques (1992-1995)

(c)DNA isolation
(c)DNA cloning
DNA sequencing (ALF automatic sequencer)
Polymerase Chain Reaction (PCR)
Polyacrylamide gel electrophoresis
Heteroduplex analysis
Restriction Enzyme Digestion (RFLP)
Agarose gel electrophoresis
Southern blotting (NaOH, SSC)
DNA labeling (fluorescent, radioactive)
DNA hybridization
Autoradiography
Colony screening
(Pulsed field gel electrophoresis)

Language skills

Nederlands (Dutch): native speaker
English: fluently
Deutsch: sehr gut
Français: base

Publications

Book chapters

Front-End Vision and Multi-Scale Image Analysis
Bart M. ter Haar Romeny
Kluwer Academic Publishers,Dordrecht, the Netherlands. 484 pp., August 2003.
Hardbound, ISBN 1 4020 1503 8
Paperback, ISBN 1 4020 1507 0
co-author of Chapter 18: Color differential structure

Journal Articles

1. Prenatal exclusion of medium-chain acyl-CoA dehydrogenase (MCAD) deficiency by direct detection of the mutation with PCR.
J. Hendrickx, P. Van Osta, F. Eyskens, Y. Matsubara, K. Narisawa and P.J. Willems
Prenatal Diagnosis, 12, pp. 74-75, 1992.

2. Belang van de DNA diagnostiek van medium-chain acyl-CoA dehydrogenase deficiëntie bij wiegedood.
J. Hendrickx, P. Van Osta, G.P.A. Smit, P. Van Reempts, K. De Boulle, P. Coucke and P.J. Willems.
Tijdschrift voor Geneeskunde, 48, pp. 1089-1093, 1992

3. Computer analysis of two-dimensional electrophoresis gels: A new segmentation and modeling algorithm.
E. Bettens, P. Scheunders, D. Van Dyck, L. Moens and P. van Osta
Electrophoresis 18, pp. 792-728, 1997

4. Processing of apolipoprotein E in cerebrospinal fluid of patients with Alzheimer's disease.
I. Stevens, P. Van Osta, H. Geerts, G. Verheyen, M.-L. Van Hauwaert, P. Cras, S. Engelborghs, P. De Deyn, J.-J. Martin, C. Van Broeckhoven and L. Moens.
Alzheimer's Reports, Volume 1, Number 4, pp. 257-265, 1998

5. Color differential structure.
B. M. ter Haar Romeny, J.-M. Geusebroek, P. Van Osta, R. van den Boomgaard and J.J. Koenderink.
Scale-Space and Morphology in Computer Vision, Third International Conference, Scale-Space 2001
Vancouver, Canada, July 7-8, 2001.
Proceedings. Lecture Notes in Computer Science 2106, Springer pp.353-361, 2001
ISBN 3-540-42317-6

6. Coexpression of GSK-3[beta] Corrects Phenotypic Aberrations of Dorsal Root Ganglion Cells, Cultured from Adult Transgenic Mice Overexpressing Human Protein tau.
R. Nuydens, G. Van Den Kieboom, C. Nolten, C. Verhulst, P. Van Osta, K. Spittaels, C. Van den Haute, E. De Feyter, H. Geerts and F. Van Leuven.
Neurobiology of Disease, Feb., 9(1), pp. 38-48, 2002

7. The principles of scale space applied to structure and colour in light microscopy.
P. van Osta, J.M. Geusebroek, K. Ver Donck, L. Bols, J. Geysen, and B. M. ter Haar Romeny.
Proceedings of the Royal Microscopical Society, Sept., 37(3), pp. 161-166, 2002.

8. In Vitro Studies of Flemish, Dutch, and Wild-Type beta-Amyloid Provide Evidence for Two-Staged Neurotoxicity.
S. Kumar-Singh, A. Julliams, R. Nuydens, C. Ceuterick, C. Labeur, S. Serneels, K. Vennekens, P. Van Osta, H. Geerts, B. De Strooper and C. Van Broeckhoven.
Neurobiology of Disease, Nov., 11(2), pp. 330-340, 2002.

9. Cytomics and drug discovery.
Van Osta P, Donck KV, Bols L, Geysen J.
Cytometry A. 2006 Feb 22;69A(3), pp. 117-118

10. Extracting quantitative information from tissue-An industrial perspective.
Van Osta P
Cytometry A. 2006 May 5; Epub

Technical notes

P. Van Osta
Digital Imaging - Nyquist sampling rate
Microscopy and Microanalysis, Volume 4, Nr. 8, pp. 371-372, 2002.

Oral Presentations

1. The Internet in biomedical research (1992, UIA, Antwerp, Belgium)
2. Informatics in genetics research (1995, UZG/RUG, Gent, Belgium)
3. PC memory management with MS-DOS 5 (1992, HCC-Belgium, Antwerp, Belgium)
4. Datacommunication I: background and technique (1992, HCC-Belgium, Antwerp, Belgium)
5. Datacommunication II: Internet, CompuServe and FidoNet (1992, HCC-Belgium, Antwerp, Belgium)
6. Multimedia: hardware requirements and applications (1992, HCC-Belgium, Antwerp, Belgium )

7. P. Van Osta, J. Van Reempts
Morphometry and neuronal plasticity.
Janssen Research Foundation, Beerse, June 1998.

8. P. Van Osta
Application of linear scale space and the spatial color model in light microscopy.
Spring Meeting NVPHBV, Amsterdam, 12 April 2000.

9. P. Van Osta, K. Ver Donck
Getting more out of your Microscope.
Janssen Research Foundation, Beerse, 24 March 2000.

10. P. Van Osta
Principles and applications of automated image analysis in clinical research and diagnostics.
Lesson in Clinical Biology, U.Z. Leuven, Leuven, Belgium , 7 May 2002.

11. P. Van Osta
Automated Tiled Multi-mode Image Acquisition and Processing Applied to Pharmaceutical Research.
13th ProRISC workshop on Circuits, Systems and Signal Processing, Veldhoven, the Netherlands, 28-29 November 2002.

12. Johan Geysen et al.
Seamless integration of target validation, assay development and HTS.
Plenary Session
SMi, 3rd annual Conference on Target Validation, London, United Kingdom, 7-8 April 2003,

13. Kris Ver Donck, Peter Van Osta, Luc Bols, Bart Vanherck and Johan Geysen
Ultra-sensitive multimode microscopic reading in HTS.
Session 3C - Applications of Biological Imaging
SBS-2003, Portland, Oregon USA, Wednesday, 24 September, 2003.

14. Johan Geysen, Peter Van Osta, Luc Bols, Bart Vanherck and Kris Ver Donck
Solutions for the Challenges in High-throughput Cell Based Screening.
Plenary Session 5: From Proteins to Cells: Accelerating Cell Biology
Current Challenges In Biomolecular Screening, SEBIOT 2003, Madrid, Spain, 13-14 November, 2003

15. P. Van Osta, Bart Vanherck, Kris Ver Donck, Luc Bols and Johan Geysen
The M5 framework for exploring the cytome.
The M5 framework for exploring the cytome.
Plenary Session and Discussion: Human Cytome Project, Abstract p. 66
Focus On Microscopy (F.O.M.) 2004, Philadelphia, PA, USA, 4-7 April, 2004

16. P. Van Osta - session chair
A Human Cytome Project
Round table discussion, Session LS 18, 27 Aug. 2004, (introduction by P. Van Osta)
13th European Microscopy Congress (EMC), University of Antwerp, Antwerp, Belgium , 22-27 August, 2004

17. P. Van Osta - panel member
The Role of Instincts in Modern Society (Managing Human Instinct)
Session B-11 (4 Sept. 2004), Biobehavioral Approaches to the study of Politics: I, Abstract p. 37
24th Annual Meeting of the Association for Politics and the Life Sciences (APLS)
Hyatt Regency Hotel, Chicago, Illinois, 2-5 September, 2004

18. P. Van Osta
Cytomics in Pharmaceutical Research
7th EWGCCA Workshop, Session 2 23 Sept. 2004), Human Cytome Project
EWGCCA, 4th EUROCONFERENCE: Flow and Beyond
SCK/CEN, Mol, Belgium, 23-25 September, 2004

19. P. Van Osta
Cytomics in Drug Discovery
10th Leipziger Workshop Incorporating: 3rd International Workshop Slide-Based Cytometry
Heart Centre Leipzig GmbH and Max-Buerger-Research Centre, Leipzig Germany, 7-9 April

20. Johan Geysen, Peter Van Osta,Luc Bols, Bart Vanherck and Kris Ver Donck
Current and Future Applications of Automated Microscopy in Biotechnology and Drug Discovery Research
‘Knowledge for Growth’ Conference, Flanders Expo, Gent, 3 June 2005

21. Kris Ver Donck, Peter Van Osta, Luc Bols, Marc Moeremans, Leen Geuens, Bieke Govaerts and Johan Geysen
Non-Invasive Assessment of Cell Growth, Confluence and Compound-induced Inhibition on Unlabelled Primary Human Cell Cultures
SBS 2005, Geneva Switzerland, September 2005

Poster presentations

1. D. Balériaux, Z. Patay, J. Brotchi, F. Rio, I. Salmon, P. Van Osta.
CD-ROM MRI of Spinal Cord Disease: a CD ROM tutorial
XV Symposium Neuroradiologicum, Kumamato 25 sept - 1 Okt., Japan

2. P. Van Osta, D. Balériaux, J. Brotchi et al.
CD-ROM MRI of Spinal Cord Tumors

Magna Cum Laude Citation for the scientific exhibit on the 33rd Annual Scientific Meeting of the American Society of Neuroradiology (ASNR) - Chicago, April 1995.
Prix Special Informag de 43eme journées Françaises de radiologie - Oktober 1995

3. Study of CSF in Alzheimer Dementia: Two-Dimensional Polyacrylaminde Gel Electrophoresis and Computer Image Analysis.
L. Moens, I. Stevens, P. Van Osta, ML. Van Hauwaert, P. Cras, P.P. De Deyn, H. Geerts, J-J. Martin.
2nd Siena 2D Electrophoresis Meeting, Siena (Italy) Sept. 1996.

4. The timely relationship between annexin-V-FITC staining and nucleus fragmentation in NGF-deprived PG12-cells. A multispectral microscopy study.
Gwenda Dispersyn, Peter Van Osta, Jan-Mark Geusebroek, Rony Nuydens, Roger Nuyens, Hugo Geerts
The 1997 Annual Meeting of the Belgian Society for Microscopy (BSM) took place on Saturday, November 29 at Janssen Pharmaceutica in Beerse.

5. High density C. elegans screening: a drug discovery platform applied to the steerin (Unc-53) pathway.
K. Ver Donck, I. Maillet*, I. Roelens*, L. Bols, P. Van Osta, T. Bogaert, J. Geysen
Abstract-Poster, C. elegans Meeting, Michigan, June 1999
* DeVGen, Gent, Belgium

6. High density C. elegans screening: an automated phenotype analysis platform, applied to the Unc-53 (Steerin) pathway.
Ver Donck,K. Maillet,I.* Roelens,I.* Bols,L. Van Osta,P. Bogaert,T.* Geysen,J.
Abstract-Poster, European C.elegans Meeting, May 2000
* DeVGen, Gent, Belgium

7. Application of linear scale space and the spatial color model in light microscopy.
P. Van Osta
First Discovery Day, Janssen Pharmaceutica, Beerse, Belgium, Nov. 2000

8. Color Differential Structure.
B.M. ter Haar Romeny, J.-M. Geusebroek, P. Van Osta, R. van den Boomgaard, J.J. Koenderink.
Third International Conference, Scale-Space 2001, July 7-8, Vancouver, Canada, 2001.

9. Enhanced Analytical Performance of the C. elegans Flow Sorter COPAS™ BIOSORT: Automated Re-analysis of Populations in Multi-well Plates and Reading of Axially Distributed Positional Fluorescent Signals.
J. Geysen, S. Alam*, A. Ferrante*, P. Kalutkewitz*, P. Van Osta, S. Zusman*
Poster and oral presentation, European C. elegans Meeting, Paestum (Sa), Italy, May 2002.
*Union Biometrica, Inc, Somerville, MA, USA

10. Enhanced One-step Nematode Recognition on micrographs of Living C. elegans Cultures in 384-well Plates using Linear Scale Space Mathematics.
P. Van Osta, K. Ver Donck, J.-M. Geusebroek*, L. Bols and J. Geysen
Poster, European C. elegans Meeting, Paestum (Sa), Italy, May 2002.
*Intelligent Sensory Information Systems, UvA, Amsterdam, the Netherlands

11. Assays Beyond uHTS through COPAS™ Flow Sorting.
K. Ver Donck, L. Bols, R. Bongaarts, P. Van Osta, A. J. Brouwer*, R. M. J. Liskamp* and J. Geysen
Poster, MipTec, Basel, Switzerland, June 2002
* Utrecht University, Utrecht, the Netherlands

12. At the higher End of High Content Screening: The MIAS™ HTS Imaging Device.
K. Ver Donck, P. Van Osta, L. Bols and J. Geysen
Poster, MIPTEC, Basel, Switzerland, June 2002

13. Application of linear scale space and the spatial color model in microscopy.
P. Van Osta, K. Ver Donck, L. Bols, J. Geysen, J.M. Geusebroek* and B.M.ter Haar Romeny**
Poster, Joint Microscopy Meeting, Trinoculaire (France, Switzerland, Belgium, The Netherlands), Lille, France, 25-28 June 2002
* ISIS, Faculty of Science, University of Amsterdam, Amsterdam, the Netherlands
** Technical University Eindhoven, Faculty Biomedical Technology, Biomedical Imageprocessing, Eindhoven, the Netherlands

14. The Multi-Mode Mosaic framework for automated microscopy and analysis.
P. Van Osta, K. Ver Donck, J.M. Geusebroek*, L. Bols and J.Geysen
Poster, Scientific Digital Imaging Session, MicroScience2002, International Conference and Exhibition, London, UK, 9-11 July 2002, p. 32
* ISIS, Faculty of Science, University of Amsterdam, Amsterdam, the Netherlands

15. The application of scale space and the spatial color model in microscopy.
P. Van Osta, K. Ver Donck, J.M. Geusebroek*, L. Bols, J.Geysen and B.M. ter Haar Romeny**
Poster, Image Quantitfication Session, MicroScience2002, International Conference and Exhibition, London, UK, 9-11 July 2002, p. 33
* ISIS, Faculty of Science, University of Amsterdam, Amsterdam, the Netherlands
** Technical University Eindhoven, Faculty Biomedical Technology, Biomedical Imageprocessing, Eindhoven, the Netherlands

16. Fast Assay Development for Multimode Microscopy Screening with a flexible HTS reader.
Kris Ver Donck, Luc Bols, Peter Van Osta and Johan Geysen
6th MipTec, Convention Center Basel, Basel, Switzerland, 12 - 15 May, 2003

17. Bead-Based Assays Using COPASTM Flow Sorting
Kris Ver Donck, Luc Bols, Rico Bongaarts, Peter Van Osta, Arwin J. Brouwer, Rob M. J. Liskamp, Johan Geysen, Don Perrault, Rock Pulak
European Symposium on Combinatorial Sciences, Eurocombi, Copenhagen, 29 June - 3 July, 2003

18. Time-lapse projection of real time video reveals substantial detail of C. elegans locomotion on agarose and swimming in liquid culture.
Kris Ver Donck, Peter Van Osta, Luc Bols, Rock Pulak, Johan Geysen
14th Biennial International C. elegans Conference, UCLA, Los Angeles, USA, 29 June - 3 July, 2003

19. Automated assessment of cell growth, confluence and compound-induced inhibition using unlabeled skin-derived cells and brightfield microscopy
Johan Geysen, Luc Bols, Kim Franssen, Leen Geuens, Bieke Govaerts, Paul Stoppie, Kris Ver Donck, Peter Van Osta, Marcel Borgers
65th meeting of the Society for Investigative Dermatology, 28 April to 1-May, 2004

20. The role of instincts in modern society.
Peter Van Osta
Poster 64, abstract p. 182
Human Behavior and Evolution Society (HBES), Annual Meeting, Berlin, 21-25 July 2004

21. A system designed for exploring the human cytome.
Peter Van Osta, Bart Vanherck, Kris Ver Donck, Luc Bols and Johan Geysen
Session IM 11: New microscopies and novelties.
Poster IM11.P04 Proceedings Vol. I, Instrumentation and Methodology, Abstract pp. 401-402
13th European Microscopy Congress (EMC), University of Antwerp, Antwerp, Belgium , 22-27 August, 2004

22. A modular and flexible Solution-On-Demand model for clinical development.
Tom Van Aken, Erik Evens, Glenn Van Dael, Peter Van Osta
Convention book, Poster 63, p. 346
Knowledge for Growth, Annual Flemish Biotech Convention, 16 June 2006, Gent, Belgium.

Publications on CD-ROM

1. H. Degryse, E. Van Moer, H. Fierens, M. Cremer, J. Devière, O. Le Moine.
CD-Gastro volume 1, Radiology and endoscopy of the upper GI tract, a professional service for medical training and information (French, Dutch - edition 1994).
Publication of Lasion Europe N.V. in collaboration with Astra-Pharmaceuticals Bio-Therabel, Belgium.

2. CD-ROM, Superficial mycoses from head to toe (Dutch, French, English - edition 1994)
Publication of Lasion Europe N.V. in collaboration with Janssen Pharmaceutica, Belgium

3. CD-ROM, Modern Medicine, Aesculapius Ceremony 1994 (English)
Publication of Lasion Europe N.V. in collaboration with Advanstar Communications USA

4. D. McLean, A. Sober
CD-ROM Illustrated Dermatology: synopsis of diagnosis and treatment
Publication of Lasion Europe N.V. in collaboration with Advanstar Communications USA (edition 1994/1995)

On-line articles

1. Nyquist Sampling in Digital Microscopy

2. Biomedical Structural Research

Workshops and Conferences

- BVM/SBM Technical Workshop on Input, Storage, Archive, Transmission and Output of Images, 12 September 1997, RUCA, Antwerp, Belgium
- Janssen-day, Growth and differentiation, Vaeshartelt conference center, 14 October 1997, Maastricht, the Netherlands
- BVM/SBM Technical Workshop on Images, R.U.C.A., 12 December 1997, Antwerpen, Belgium
- Fallmeeting NVvM, Fall 1999, Papendrecht, the Netherlands,
- Spring 2000 Meeting of the NVPHBV, April 2000, Amsterdam, the Netherlands
- First Dutch Workshop on Colour Imaging and Vision ,22 Nov. 2000, Amsterdam, the Netherlands
- Fall 2001 Meeting of the NVPHBV, 14 November 2001, Eindhoven, the Netherlands
- Spring 2002 Meeting of the NVPHBV, 15 May 2002, Amsterdam, the Netherlands
- MIPTEC, May 2002, Basel, Switzerland
- Trinoculaire, Joint Microscopy Meeting, June 2002, Lille, France
- Microscience 2002, July 2002, London, UK
- SBS, September 2002, the Hague, the Netherlands
- 13th ProRISC, November 2002, Veldhoven, the Netherlands
- MipTec, May 2002, Basel, Switzerland
- Focus On Microscopy, April 2004, Philadelphia, USA
- ISAC XXII, May 2004, Montpellier France
- European Microscopy Congress, August 2004, Antwerp; Belgium
- EWGCCA, September 2004, Mol, Belgium
- 10th Leipziger Workshop, Leipzig, Germany
-Flandersbio, bioscope-IT workshop on exerpiment design, co-chair of early clinical development session. t Pand, Gent, 10 March 2006.

Memberships


FlandersBio and BioScope-IT
eHealth Agoria (company membership)
ADM
Europese Beweging België / Mouvement Européen Belgique
Vlaamse Management Associatie (VMA)
Beheerraad bibliotheek en gemeenschapscentrum Malle
Domein de Renesse vzw
Cofounder of the Hoge Raad voor Ambachtelijke Lambiekbieren (H.O.R.A.L.), Beersel, Belgium
Academic year 1989-1990: member educational committee U.I.A., Antwerp, Belgium.
Academic year 1989-1990 en 1990-1991: movie manager student workgroup (STUWER) U.I.A., Antwerp, Belgium.
From 1993 until 1994 co-coordinator MS-DOS gg HCC-Belgium, Antwerp, Belgium.
In 1995 co-coordinator Internet-workgroup HCC (started this initiative), Antwerp, Belgium.

References

Available on request.

Email: pvosta at cs dot com